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Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
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A sympathetic brake on gut GLP-1 release

Antonio J López-Gambero1, Victor Jouque1, Daniela Cota1

  • 1University of Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000 Bordeaux, France.

Neuron
|March 21, 2024
PubMed
Summary

Adrenergic signaling inhibits glucagon-like peptide 1 (GLP-1) secretion after meals. This process elevates blood glucose and impairs brain glucose uptake, negatively impacting cognitive function.

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