Perivascular fat tissue and vascular aging: A sword and a shield
Yan Wang1, Xianmin Wang2, Yang Chen3
1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Pharmacological Research
|March 21, 2024
Summary
Perivascular adipose tissue (PVAT) plays a crucial role in vascular aging, shifting from protective to detrimental functions. Targeting PVAT offers a promising therapeutic strategy for mitigating age-related vascular disorders.
Area of Science:
- Vascular Biology
- Adipose Tissue Biology
- Aging Research
Background:
- Perivascular adipose tissue (PVAT) is increasingly recognized for its significant role in regulating vascular health and disease.
- PVAT exerts endocrine and paracrine effects through bioactive chemical production, influencing vascular homeostasis.
- Dysregulation of PVAT function, including shifts in inflammatory and metabolic profiles, is implicated in vascular aging.
Purpose of the Study:
- To review the current understanding of PVAT's role in vascular aging.
- To elucidate the molecular mechanisms of PVAT-vasculature crosstalk in aging.
- To evaluate the therapeutic potential of targeting PVAT for vascular age-related disorders.
Main Methods:
- Comprehensive literature review of PVAT biology and vascular aging.
- Analysis of molecular mechanisms underlying PVAT-vasculature interactions.
- Evaluation of clinical correlations and therapeutic strategies.
Main Results:
- PVAT function and secretory profile change during vascular aging, potentially promoting inflammation and adverse lipid metabolism.
- The interaction between PVAT and vasculature is reciprocal, with aging indicators influencing PVAT biology.
- PVAT exhibits distinct architectural and biological traits relevant to vascular aging.
Conclusions:
- PVAT is a critical regulator of vascular aging, with its functional shift contributing to age-related vascular pathology.
- Targeting PVAT presents a promising therapeutic avenue for mitigating vascular aging and associated disorders.
- Advancements in technology offer new possibilities for PVAT-targeted interventions.
Keywords:
Cardiovascular and cerebrovascular diseasesInflammatory responsePerivascular adipose tissueVascular agingMore Related Videos
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