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Published on: July 21, 2016
Beyond 2D: Novel biomaterial approaches for modeling the placenta
Samantha G Zambuto1, Adrienne K Scott2, Michelle L Oyen3
1Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA; Center for Women's Health Engineering, Washington University in St. Louis, St. Louis, MO, USA.
This review explores advanced 3D biomaterial models for placenta research, covering cell sources, biomaterials, and fabrication techniques. These models offer potential to address health disparities and study sexual dimorphism in placental development.
Area of Science:
- Biomaterials Science
- Reproductive Biology
- Tissue Engineering
Background:
- Placental research traditionally relies on simpler models.
- Understanding complex placental interactions requires advanced in vitro systems.
- Existing biomaterial scaffolds need optimization for placental applications.
Purpose of the Study:
- To review three-dimensional (3D) biomaterial environments for placental research.
- To discuss advancements in placental cell sources and biomaterial design.
- To explore the potential of 3D placenta models in addressing health disparities and sexual dimorphism.
Main Methods:
- Review of literature on 3D biomaterials and placental research.
- Analysis of placental cell sources and their interactions.
- Discussion of biomaterial properties, characterization, and fabrication techniques (e.g., microfluidics, 3D bioprinting).
Main Results:
- Development of complex 3D biomaterial environments for placental research.
- Integration of various placental cell types within engineered scaffolds.
- Characterization of biomaterials for specific placental functions.
Conclusions:
- 3D biomaterial environments are crucial for advancing in vitro placenta research.
- Advanced fabrication methods enable more physiologically relevant models.
- These models hold promise for investigating health disparities and sexual dimorphism in placental function.
