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The association between genetic polymorphisms of matrix metalloproteinases and knee osteoarthritis: A systematic

Xu Jiang1, Qianqian Wang2, Chao Wang2

  • 1Department of Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.

International Journal of Rheumatic Diseases
|March 22, 2024
PubMed
Abstract

Insights

Matrix metalloproteinase (MMP) gene polymorphisms MMP-3 and MMP-13 are linked to knee osteoarthritis (OA) risk, particularly in Asian populations. MMP-1 gene variants showed no significant association with OA development.

Area of Science:

  • Genetics and molecular biology
  • Rheumatology and orthopedics
  • Biostatistics

Background:

  • Osteoarthritis (OA) is a degenerative joint disease with a complex etiology.
  • Matrix metalloproteinases (MMPs) play a crucial role in extracellular matrix remodeling and OA pathogenesis.
  • Investigating the association between MMP gene polymorphisms and knee OA risk is essential for understanding disease mechanisms.

Approach:

  • A systematic meta-analysis was conducted, pooling data from nine case-control studies.
  • Studies were retrieved from major databases including PubMed, Embase, and SinoMed up to November 2020.
  • Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the association between MMP gene polymorphisms and knee OA.

Key Points:

  • MMP-1-1607 (rs1799750) 1G/2G polymorphism was not significantly associated with knee OA risk across various genetic models.
  • MMP-3 C/T polymorphism, particularly in its dominant model, showed a significant association with increased knee OA risk, especially in Asian ethnicity.
  • MMP-13 C/T polymorphism variants were significantly associated with an increased risk of knee OA development, notably in Asian populations under dominant and homozygote models.

Conclusions:

  • MMP gene polymorphisms, specifically MMP-3 and MMP-13, are implicated in the pathogenesis of knee OA.
  • The association between MMP-3 and MMP-13 polymorphisms and knee OA risk is particularly pronounced in Asian ethnicity.
  • MMP-1 gene polymorphisms do not appear to be a significant risk factor for knee OA.
Keywords:
MMPsmeta‐analysisosteoarthritispolymorphism

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