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  11. Prognostic Value Of Lymphocyte-to-monocyte Ratio (lmr) In Patients With Prostate Cancer: A Systematic Review And Meta-analysis.

Prognostic Value of Lymphocyte-to-Monocyte Ratio (LMR) in Patients With Prostate Cancer: A Systematic Review and Meta-Analysis.

Qin Xiang1, Yueguang Liu1, Junwen Xiao1

  • 1Department of Urology, Shenzhen Bao'an District Songgang People's Hospital, Shenzhen, China.

American Journal of Men'S Health
|March 22, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

A higher lymphocyte-to-monocyte ratio (LMR) indicates a better prognosis for prostate cancer (PCa) patients. This biomarker can help predict long-term outcomes and inform treatment decisions.

Area of Science:

  • Oncology
  • Hematology
  • Biomarkers

Background:

  • Prognostic value of lymphocyte-to-monocyte ratio (LMR) in prostate cancer (PCa) requires further investigation.
  • Identifying reliable biomarkers is crucial for predicting PCa patient outcomes and guiding clinical management.

Approach:

  • A comprehensive meta-analysis was conducted, searching multiple databases (PubMed, Web of Science, Embase, etc.) for relevant studies up to March 2023.
  • Six studies involving 1,104 PCa patients were included.
  • Newcastle-Ottawa Scale assessed study bias; Stata 15.0 performed data analysis using hazard ratios (HRs) and 95% confidence intervals (CIs).

Key Points:

  • Low LMR was associated with significantly worse overall survival (OS; HR = 1.73) and progression-free survival (PFS; HR = 2.63) in PCa patients.
  • High LMR correlated with improved OS and PFS, suggesting a better prognosis.
Keywords:
lymphocyte-to-monocyte ratio (LMR)meta-analysisprognostic valueprostate cancer (PCa)

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  • LMR emerged as an independent risk factor influencing long-term PCa prognosis.

    • Conclusions:

    • Elevated LMR in PCa patients indicates a favorable prognosis compared to those with low LMR.
    • Pre-treatment LMR assessment is valuable for predicting clinical outcomes in prostate cancer.
    • LMR serves as a significant prognostic indicator for long-term survival in prostate cancer.