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Serum Uric Acid Levels among Chinese Children: Reference Values and Association With Overweight/Obesity

Wenjing Ye1, Xinhe Zhou1, Yanping Xu1

  • 1The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Clinical Pediatrics
|March 22, 2024
PubMed

Insights

Serum uric acid (SUA) reference values in children were established. Elevated SUA levels are strongly linked to increased risk of overweight and obesity in pediatric populations.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Biochemistry
  • Public Health Nutrition

Background:

  • Serum uric acid (SUA) is a metabolic byproduct with potential links to metabolic health.
  • Establishing accurate reference ranges for SUA in children is crucial for clinical assessment.
  • The association between SUA levels and pediatric overweight/obesity requires further investigation.

Purpose of the Study:

  • To determine age- and sex-specific reference values for serum uric acid (SUA) in Chinese children.
  • To investigate the correlation between SUA levels and the prevalence of overweight and obesity in this pediatric cohort.

Main Methods:

  • Retrospective analysis of 8522 children aged 2-18 years in China.
  • Calculation of age- and sex-specific 95% reference intervals for SUA.
  • Statistical analysis of the association between SUA quartiles and overweight/obesity status.

Main Results:

  • SUA levels increased with age in normal-weight children, with significant sex differences emerging after age 10.
  • Established age- and sex-specific 95% reference intervals for SUA.
  • A significant positive correlation was found between higher SUA quartiles and increased odds of overweight/obesity (OR = 4.45).

Conclusions:

  • The 97.5th percentile of SUA is proposed as a threshold for elevated levels in children.
  • Elevated serum uric acid levels are significantly associated with a higher likelihood of overweight and obesity in children.
  • These findings highlight SUA as a potential indicator for metabolic health monitoring in pediatric populations.

Keywords:
childrenobesityoverweightreference valuesuric acid

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