GPX8+ cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment
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View abstract on PubMed
Summary
This summary is machine-generated.Cancer-associated fibroblasts (CAFs) promote lung adenocarcinoma (LUAD) progression. This study identifies glutathione peroxidase 8 (GPX8) as a key gene in CAFs, linking it to poor prognosis and immune suppression, suggesting GPX8 as a therapeutic target for LUAD.
Area Of Science
- Oncology
- Cancer Biology
- Immunology
Background
- Cancer-associated fibroblasts (CAFs) are key players in the lung adenocarcinoma (LUAD) tumor microenvironment.
- CAFs are frequently linked to adverse clinical outcomes in LUAD patients.
Purpose Of The Study
- To identify CAF-specific genes as potential therapeutic targets for LUAD.
- To investigate the role of glutathione peroxidase 8 (GPX8) in LUAD progression and the tumor microenvironment.
Main Methods
- Single-cell transcriptional profiling of LUAD fibroblasts.
- Weighted gene co-expression network analysis (WGCNA) and univariate Cox analysis to identify key genes.
- Analysis of GPX8 expression in LUAD cohorts, immune infiltration, and immunotherapy response using TIDE algorithm.
Main Results
- Glutathione peroxidase 8 (GPX8) was identified as a key gene associated with CAFs in LUAD.
- GPX8 expression correlated with poor prognosis and the induction of an immunosuppressive tumor microenvironment.
- Low GPX8 expression predicted better response to immunotherapy, and beta-CCP was identified as a potential therapeutic drug.
Conclusions
- GPX8+ CAFs are associated with poor prognosis and immune suppression in LUAD.
- Targeting GPX8+ CAFs presents a potential therapeutic strategy for LUAD treatment.
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