Trends in survival of ovarian clear cell carcinoma patients from 2000 to 2015
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View abstract on PubMed
Summary
This summary is machine-generated.Survival outcomes for ovarian clear cell carcinoma (OCCC) significantly improved from 2000-2015. Younger patients and those with distant stage disease saw the greatest survival gains in this population-based study.
Area Of Science
- Gynecologic Oncology
- Cancer Epidemiology
- Clinical Outcomes Research
Background
- Ovarian clear cell carcinoma (OCCC) is a distinct subtype of ovarian cancer.
- Understanding temporal trends in survival outcomes is crucial for evaluating treatment advancements.
Purpose Of The Study
- To analyze changes in survival outcomes for ovarian clear cell carcinoma (OCCC) patients treated over a 16-year period.
- To identify prognostic factors influencing survival in OCCC.
Main Methods
- Retrospective analysis of 4257 OCCC patients from the SEER database (2000-2015).
- Statistical analyses included Joinpoint Regression, Kaplan-Meier, and multivariate Cox regression.
- Ovarian cancer-specific survival (OCSS) and overall survival (OS) were assessed by year of diagnosis and SEER stage.
Main Results
- Significant improvements in OCSS (P=0.014) and OS (P=0.006) were observed over time.
- Year of diagnosis was an independent prognostic factor for OCSS (P=0.004) and borderline for OS (P=0.060).
- Patients with distant stage disease showed significant survival trends, particularly those aged <65 years and treated with surgery and chemotherapy.
Conclusions
- Survival outcomes for OCCC have significantly increased between 2000 and 2015.
- Younger patients (<65 years) and those with distant stage disease experienced greater survival improvements.
- Treatment strategies and earlier diagnosis may contribute to improved outcomes in OCCC.
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