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Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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  11. Identification And Validation Of Prognostic And Immunotherapeutic Responses In Esophageal Squamous Carcinoma Based On Hypoxia Phenotype-related Genes

Identification and validation of prognostic and immunotherapeutic responses in esophageal squamous carcinoma based on hypoxia phenotype-related genes

Kai Xie1, Zhe Chen1, Jian Feng2

  • 1Department of Thoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.

Frontiers in Pharmacology
|March 22, 2024

Related Experiment Videos

Development of Compendium for Esophageal Squamous Cell Carcinoma
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Development of Compendium for Esophageal Squamous Cell Carcinoma

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Induction and Testing of Hypoxia in Cell Culture
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Induction and Testing of Hypoxia in Cell Culture

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In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

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View abstract on PubMed

Summary
This summary is machine-generated.

This study introduces a new hypoxia phenotype-related gene score (HPRscore) and PKP1 as prognostic markers for esophageal squamous cell carcinoma (ESCC), aiding in predicting treatment response.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • The tumor microenvironment, particularly hypoxia, significantly influences immune responses in esophageal squamous cell carcinoma (ESCC).
  • Understanding the interplay between hypoxia and immunity is crucial for developing effective ESCC therapies.

Purpose of the Study:

  • To investigate the clinical significance of hypoxia phenotype-related genes (HPRs) in the ESCC microenvironment.
  • To identify novel prognostic biomarkers and therapeutic targets for ESCC.

Main Methods:

  • Utilized TCGA-ESCC and GEO cohort data for comprehensive evaluation of 13 HPRs.
  • Developed and validated an HPRscore as a prognostic factor and predictor of immunotherapy/chemotherapy outcomes.
  • Conducted phenome-wide association study (PheWAS) and in vitro experiments to assess the role of PKP1.
Keywords:
PKP1PheWASPrognosisesophageal squamous cell carcinoma

Related Experiment Videos

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

409
Induction and Testing of Hypoxia in Cell Culture
07:01

Induction and Testing of Hypoxia in Cell Culture

Published on: August 12, 2011

84.9K
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

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Main Results:

  • Identified three distinct HPR clusters and established the HPRscore as an independent prognostic factor (p = 0.001), with higher scores correlating with poorer prognosis.
  • Validated the HPRscore's efficacy in predicting immunotherapy and chemotherapy responses.
  • Identified PKP1 as a potential prognostic marker with upregulated expression in ESCC; PKP1 knockdown inhibited ESCC cell proliferation and migration.

Conclusions:

  • The novel HPRscore serves as a valuable prognostic tool for esophageal squamous cell carcinoma.
  • PKP1 demonstrates potential as both a prognostic marker and a therapeutic target for ESCC patients.
hypoxia
immunotherapy
tumor microenvironment