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Related Experiment Video

Updated: Jun 30, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Association between gut microbiota and menstrual disorders: a two-sample Mendelian randomization study.

Yufan Yao1, Haoran Hu2, Longhao Chen3

  • 1College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, China.

Frontiers in Microbiology
|March 22, 2024
PubMed
Summary

This study suggests a causal link between gut microbiota and menstrual disorders. Specifically, Escherichia/Shigella bacteria were found to be associated with menstrual disorders, opening new avenues for research.

Keywords:
Mendelian randomizationSNPsgeneticsgut microbiotamenstrual disorder

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Area of Science:

  • Microbiome research
  • Gynecological health
  • Genetic epidemiology

Background:

  • Emerging evidence links gut microbiota to gynecological diseases.
  • The causal relationship between gut microbiota and menstrual disorders requires further investigation.

Purpose of the Study:

  • To investigate the potential causal association between gut microbiota and menstrual disorders using a bidirectional Mendelian randomization approach.

Main Methods:

  • Utilized summary data from MiBio-Gen for gut microbiota and the IEU Open GWAS project for menstrual disorders.
  • Employed multiple Mendelian randomization methods (MR-Egger, weighted median, inverse variance weighted, simple mode, weighted mode).
  • Conducted sensitivity analyses to assess pleiotropy, heterogeneity, and robustness.

Main Results:

  • Identified a potential causal link between 23 gut microbiota and menstrual disorders.
  • After FDR correction, Escherichia/Shigella demonstrated a significant association with menstrual disorders (p=0.00032, P_FDR=0.0382, OR=1.004).

Conclusions:

  • Mendelian randomization analysis indicates a causal relationship between gut microbiota and menstrual disorders.
  • Findings may inform future research on the mechanisms of menstrual disorders and microbiota-targeted therapies.