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Related Concept Videos

Overview of Algae01:28

Overview of Algae

The kingdom Archaeplastida encompasses red and green algae, along with land plants. Unlike other protists with chloroplasts that arose through secondary endosymbiosis, only red and green algae originated from primary endosymbiotic events. This diverse group of eukaryotic organisms contains chlorophyll and performs oxygenic photosynthesis.Algae exist in various forms, from large brown kelp in coastal waters to green scum in puddles and stains on rocks or soil. Some species are responsible for...
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Red algae, also known as rhodophytes, are primarily found in marine environments, though some species inhabit freshwater and terrestrial ecosystems. These organisms exist in both unicellular and multicellular forms, with some multicellular varieties reaching macroscopic sizes.As phototrophic organisms, red algae contain chlorophyll a; however, their chloroplasts lack chlorophyll b. Instead, they possess phycobiliproteins, which serve as major light-harvesting pigments, similar to those found in...
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Updated: Jun 16, 2026

High-Throughput Metabolic Profiling for Model Refinements of Microalgae
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Genome editing in macroalgae: advances and challenges.

Jonas De Saeger1, Emma Coulembier Vandelannoote2,3,4, Hojun Lee1

  • 1Bio Environmental Science and Technology (BEST) Lab, Ghent University Global Campus, Yeonsu-gu, Republic of Korea.

Frontiers in Genome Editing
|March 22, 2024
PubMed
Summary
This summary is machine-generated.

Genome editing in macroalgae is emerging, with CRISPR established in some species but limited by low efficiency. Advancing stable transformation and understanding DNA repair are key to unlocking macroalgae

Keywords:
CRISPRgenome editingmacroalgaereverse geneticsseaweed biotechnologyseaweed breeding

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Area of Science:

  • Marine Biology
  • Molecular Biology
  • Biotechnology

Background:

  • Macroalgae hold significant ecological and economic importance.
  • Genome editing applications in macroalgae are currently limited, primarily to proof-of-concept studies.
  • Existing research has demonstrated CRISPR functionality in specific brown and green seaweed species.

Purpose of the Study:

  • To review the current status and challenges of genome editing in macroalgae.
  • To identify key areas for technological advancement to facilitate broader application of genome editing.
  • To highlight the potential impact of efficient genome editing on macroalgae research and development.

Main Methods:

  • Review of existing literature on genome editing in macroalgae.
  • Analysis of current limitations, including low editing efficiencies and the need for auxiliary technologies.
  • Discussion of the role of DNA repair mechanisms in editing outcomes.

Main Results:

  • CRISPR functionality has been confirmed in *Ectocarpus* species and *Saccharina japonica* (brown algae) and *Ulva prolifera* (green algae).
  • Low editing efficiencies necessitate the co-targeting of *ADENINE PHOSPHORIBOSYL TRANSFERASE* for mutant enrichment.
  • Significant challenges remain in stable transformation and understanding DNA repair pathways.

Conclusions:

  • Advancing stable transformation technologies is crucial for screening novel editing reagents.
  • Further research into DNA repair mechanisms is essential for improving editing outcomes.
  • Development of efficient genome editing tools will enable gene characterization and enhance breeding programs for improved macroalgae strains with higher yields, valuable compounds, and climate resilience.