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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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  11. Immune Signature Of Small Bowel Adenocarcinoma And The Role Of Tumor Microenvironment

Immune signature of small bowel adenocarcinoma and the role of tumor microenvironment

Grigorios Christodoulidis1, Marina Nektaria Kouliou2, Konstantinos Eleftherios Koumarelas2

  • 1Department of General Surgery, University Hospital of Larissa, Larissa 41110, Greece. gregsurg09@gmail.com.

World Journal of Gastroenterology
|March 22, 2024

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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
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View abstract on PubMed

Summary
This summary is machine-generated.

Programmed cell death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes in small bowel adenocarcinoma (SBA) impact prognosis. Evaluating the tumor immune microenvironment, especially microsatellite instability (MSI) status, is crucial for treatment decisions.

Area of Science:

  • Gastrointestinal Oncology
  • Cancer Immunology
  • Tumor Microenvironment Research

Background:

  • Small bowel adenocarcinoma (SBA) is a rare cancer with a poor prognosis due to late detection and limited treatment options.
  • The small intestine's unique characteristics, including rapid cell turnover and an active immune system, influence SBA development and immune cell infiltration.
  • Programmed cell death-ligand 1 (PD-L1) expression and microsatellite instability (MSI) are key factors in various cancers, but their prognostic significance in SBA requires further elucidation.
Keywords:
Microsatellite instabilityProgrammed cell death 1Programmed cell death-ligand 1Programmed death ligand

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Small bowel adenocarcinoma
Tumor infiltrating lymphocytes
Tumor microenvironment