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Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
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Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian
Yuanxiao Ying1, Ze Yu2, Liping Wu3
1Department of Pediatrics, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, China.
Frontiers in Endocrinology
|March 22, 2024
Summary
This study found a causal link between plasma eIF4G levels and central precocious puberty (CPP). Lower eIF4G may be associated with reduced CPP risk, warranting further investigation for therapeutic potential.
Area of Science:
- Endocrinology
- Genetics
- Proteomics
Background:
- The mechanistic target of rapamycin (mTOR) pathway influences central precocious puberty (CPP).
- The precise causal relationship between mTOR-dependent proteins and CPP remains undetermined.
Purpose of the Study:
- To investigate the causal effects of seven mTOR-dependent circulating protein levels on CPP using Mendelian randomization (MR).
Main Methods:
- A two-sample MR design was employed.
- Instrumental variables for protein levels were sourced from proteomics-GWAS (INTERVAL) and eQTLGen.
- CPP genetic data were obtained from the FinnGen Consortium; inverse-variance weighted (IVW) analysis was primary, with sensitivity analyses for pleiotropy, heterogeneity, and robustness.
Main Results:
- A significant inverse causal association was found between plasma eIF4G levels and CPP.
- This association was consistent in both discovery (OR = 0.45, p = 0.026) and validation (OR = 0.45, p = 0.014) cohorts.
Conclusions:
- Plasma eIF4G levels are causally associated with central precocious puberty.
- Further research is needed to explore the potential of eIF4G in CPP prevention or treatment.
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