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Updated: Jun 30, 2025
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Mortality Analysis in Geriatric Patients With Acute Kidney Injury Admitted in the Intensive Care Unit: A
Girish V Kumthekar1, Veena Purandare2, Manasi Nagarkar2
1Nephrology, Symbiosis Medical College for Women, Symbiosis University Hospital and Research Centre, Symbiosis International University, Pune, IND.
Cureus
|March 22, 2024
Summary
Acute kidney injury (AKI) in older adults is often caused by drugs or obstructive nephropathy. These conditions significantly increase the risk of mortality during hospitalization.
Area of Science:
- Nephrology
- Geriatrics
- Internal Medicine
Background:
- Acute kidney injury (AKI) is a critical condition characterized by a rapid decline in kidney function, leading to waste product accumulation.
- Geriatric populations are particularly vulnerable to AKI due to age-related physiological changes and increased comorbidities.
Purpose of the Study:
- To investigate the primary causes, severity, and in-hospital outcomes of acute kidney injury in patients over 60 years old.
- To identify specific etiologies and management strategies associated with mortality in geriatric AKI patients.
Main Methods:
- A 12-month cross-sectional study conducted from February 2015 to January 2016.
- Inclusion criteria: patients aged over 60 diagnosed with AKI.
- Data collected on etiology, severity (KDIGO criteria), management, and hospital outcomes.
Main Results:
- Common AKI etiologies included drug-induced (25%), respiratory (20%), age-related (21.67%), tropical (15%), pancreatitis (15%), and cardiac (13.33%).
- Obstructive nephropathy was a predominant cause (55%), associated with the highest mortality rate (37.5%).
- Conservative management without renal replacement therapy had a 39% mortality rate; no significant mortality difference was observed across KDIGO classes (p=0.177).
Conclusions:
- Drug-induced AKI and obstructive nephropathy are significant contributors to hospital mortality in the geriatric population.
- Identifying and managing these specific AKI causes is crucial for improving outcomes in elderly patients.
- Further research into targeted interventions for high-risk geriatric AKI patients is warranted.
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