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Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review)

Maximo Berto Martinez Benitez1, Yussel Pérez Navarro1, Elisa Azuara-Liceaga1

  • 1Postgraduate Program in Genomic Sciences, Science and Technology School, Autonomous University of Mexico City, Mexico City, CP 03100, Mexico.

International Journal of Molecular Medicine
|March 22, 2024
PubMed

Insights

Circular RNAs (circRNAs) regulate gene expression and are linked to diseases like diabetes. This review explores circRNAs in diabetic nephropathy and their interaction with transcription factors.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are non-coding RNA molecules regulating gene expression at multiple levels.
  • circRNAs are implicated in various human diseases, including metabolic disorders like diabetes and its complications.
  • Diabetic nephropathy is a significant complication of diabetes mellitus, involving complex cellular processes.

Purpose of the Study:

  • To review the biogenesis and functions of circRNAs.
  • To summarize the role of circRNAs in cellular processes relevant to diabetic nephropathy.
  • To report novel potential interactions between circRNAs and transcription factors (c-Jun, c-Fos) in high-glucose conditions.

Main Methods:

  • Literature review of circRNA biogenesis, function, and roles in diabetic nephropathy.
  • Analysis of existing research on circRNAs in kidney cells under high-glucose conditions.
  • Identification of potential interactions between specific circRNAs and transcription factors.

Main Results:

  • circRNAs play critical roles in regulating gene expression, impacting cellular functions.
  • Dysregulated circRNAs are associated with the pathogenesis of diabetic nephropathy.
  • Potential novel interactions between circRNAs and transcription factors c-Jun and c-Fos in renal cells exposed to high glucose were identified.

Conclusions:

  • circRNAs are key regulators implicated in diabetic nephropathy.
  • Understanding circRNA functions and interactions offers potential therapeutic targets for diabetic kidney disease.
  • Further research into circRNA-transcription factor interactions is warranted for diabetic nephropathy treatment.
Keywords:
RNA‑binding proteinscircular RNAsc‑Fosc‑Jundiabetic nephropathynon‑coding RNAs

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