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Hypodermis

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...

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Updated: Jun 30, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Deciphering adipose development: Function, differentiation and regulation.

Ge Guo^1,2, Wanli Wang^1,2, Mengjie Tu^1,2

¹Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, China.

Developmental Dynamics : an Official Publication of the American Association of Anatomists

|March 22, 2024

Summary

This summary is machine-generated.

Obesity, driven by excess fat storage in adipose tissues, is a major health risk. Understanding adipogenesis, the process of fat cell formation, offers strategies to combat obesity and related diseases.

Keywords:

adipose development differentiation obesity

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Last Updated: Jun 30, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

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Published on: June 3, 2016

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

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Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Area of Science:

Biomedical Science
Metabolic Research
Obesity Studies

Background:

Adipose tissue overdevelopment and lipid accumulation cause obesity.
Obesity is a significant risk factor for hypertension, diabetes, osteoarthritis, and cancers.
Controlling adipose tissue development is crucial for preventing obesity-related diseases.

Purpose of the Study:

To provide a comprehensive review of adipose tissue development.
To elucidate the molecular mechanisms underlying adipogenesis.
To identify potential therapeutic strategies for obesity management.

Main Methods:

Literature review of adipose tissue development.
Analysis of factors regulating adipogenesis (hormones, cytokines, diet).
Examination of molecular mechanisms of adipocyte differentiation.

Main Results:

Adipogenesis is regulated by hormones, cytokines, gender, and diet.
Excess lipid accumulation occurs via adipocyte hypertrophy or hyperplasia.
A thorough understanding of adipose development is presented.

Conclusions:

Understanding adipose development offers therapeutic targets for obesity.
Strategies can be developed to manage obesity without compromising adipose tissue function.
This review consolidates knowledge on adipogenesis for future research and clinical application.