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Aging01:26

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Exercise to Mitigate Cerebrovascular Aging: A Geroscience Perspective.

Amani M Norling1,2, Lewis A Lipsitz1,2

  • 1The Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|March 22, 2024
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Summary
This summary is machine-generated.

Exercise may combat aging by targeting key cellular processes. Understanding how exercise benefits the brain can promote healthier aging and cognitive function.

Keywords:
BrainCardiorespiratory fitnessCognitionHallmarks of aging

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Area of Science:

  • Gerontology and Exercise Science
  • Cellular and Molecular Biology
  • Neuroscience and Aging

Background:

  • Aging involves a decline in cellular functions, increasing risks for chronic diseases, vascular issues, and neurodegeneration.
  • Geroscience identifies hallmarks of aging (e.g., genomic instability, cellular senescence) as intervention targets.
  • Exercise shows potential anti-aging properties, but brain-specific mechanisms are not fully understood.

Purpose of the Study:

  • To explore how exercise interventions impact the hallmarks of aging.
  • To elucidate the mechanisms by which exercise benefits brain health.
  • To support the role of adaptive exercise responses in mitigating age-related brain changes.

Main Methods:

  • Review of current scientific literature on aging hallmarks and exercise.
  • Analysis of studies investigating exercise's effects on cellular and molecular aging processes.
  • Synthesis of findings related to exercise, cerebrovascular health, and brain function.

Main Results:

  • Exercise may favorably influence multiple hallmarks of aging.
  • Adaptive responses to exercise are linked to mitigating aging's effects on the brain.
  • Exercise contributes to maintaining brain function throughout the healthspan.

Conclusions:

  • Exercise plays a crucial role in addressing aging hallmarks.
  • Understanding exercise's neuroprotective effects can guide brain health strategies.
  • Targeting aging mechanisms through exercise promotes sustained cognitive function and cerebrovascular health.