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Exercise to Mitigate Cerebrovascular Aging: A Geroscience Perspective
Amani M Norling1,2, Lewis A Lipsitz1,2
1The Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
Summary
Exercise may combat aging by targeting key cellular processes. Understanding how exercise benefits the brain can promote healthier aging and cognitive function.
Area of Science:
- Gerontology and Exercise Science
- Cellular and Molecular Biology
- Neuroscience and Aging
Background:
- Aging involves a decline in cellular functions, increasing risks for chronic diseases, vascular issues, and neurodegeneration.
- Geroscience identifies hallmarks of aging (e.g., genomic instability, cellular senescence) as intervention targets.
- Exercise shows potential anti-aging properties, but brain-specific mechanisms are not fully understood.
Purpose of the Study:
- To explore how exercise interventions impact the hallmarks of aging.
- To elucidate the mechanisms by which exercise benefits brain health.
- To support the role of adaptive exercise responses in mitigating age-related brain changes.
Main Methods:
- Review of current scientific literature on aging hallmarks and exercise.
- Analysis of studies investigating exercise's effects on cellular and molecular aging processes.
- Synthesis of findings related to exercise, cerebrovascular health, and brain function.
Main Results:
- Exercise may favorably influence multiple hallmarks of aging.
- Adaptive responses to exercise are linked to mitigating aging's effects on the brain.
- Exercise contributes to maintaining brain function throughout the healthspan.
Conclusions:
- Exercise plays a crucial role in addressing aging hallmarks.
- Understanding exercise's neuroprotective effects can guide brain health strategies.
- Targeting aging mechanisms through exercise promotes sustained cognitive function and cerebrovascular health.
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