Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

6.7K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recent advances in modeling and simulation of biological phenomena in crowded and cellular environments.

Current opinion in structural biology·2026
Same author

Effectiveness of a training programme on frontline workers' skills and competencies in promoting safe and stable nurturing relationships: A quasi-experimental study from rural central India.

The Indian journal of medical research·2026
Same author

SPIRIT-Children and Adolescents (SPIRIT-C) 2026 extension statement: enhancing the reporting and usefulness of paediatric randomised trial protocols.

The Lancet. Child & adolescent health·2026
Same author

CONSORT-Children and Adolescents (CONSORT-C) 2026 extension statement: enhancing the reporting and impact of paediatric randomised trials.

The Lancet. Child & adolescent health·2026
Same author

Cost of adapting the International Guide for Monitoring Child Development, Guatemala and India.

Bulletin of the World Health Organization·2026
Same author

Mixed methods implementation evaluation of community-based intergenerational program to improve the quality of life of the elderly in rural Maharashtra.

BMC geriatrics·2026

Related Experiment Video

Updated: Jun 30, 2025

Electrophysiological Measurements and Analysis of Nociception in Human Infants
09:18

Electrophysiological Measurements and Analysis of Nociception in Human Infants

Published on: December 20, 2011

17.2K

Compensation in Neonatal Clinical Trials: A Perspective.

Apoorva Mathur1, Dilip Raja1, Anju Sinha2

  • 1Division of Reproductive, Child Health and Nutrition, Indian Council of Medical Research (ICMR), New Delhi, India.

Indian Pediatrics
|March 22, 2024
PubMed
Summary
This summary is machine-generated.

Current Indian guidelines for clinical trial compensation inadequately protect neonates. This article proposes a birthweight-based compensation formula to address this critical gap for neonatal clinical trials.

More Related Videos

Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets
06:51

Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets

Published on: December 19, 2019

6.1K
A Swine Model of Neonatal Asphyxia
10:36

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

14.3K

Related Experiment Videos

Last Updated: Jun 30, 2025

Electrophysiological Measurements and Analysis of Nociception in Human Infants
09:18

Electrophysiological Measurements and Analysis of Nociception in Human Infants

Published on: December 20, 2011

17.2K
Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets
06:51

Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets

Published on: December 19, 2019

6.1K
A Swine Model of Neonatal Asphyxia
10:36

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

14.3K

Area of Science:

  • Neonatal research
  • Clinical trial regulation
  • Medical ethics

Background:

  • Clinical trials are crucial for evidence-based medicine.
  • India has guidelines for trial participant compensation.
  • Current guidelines lack specificity for pediatric and neonatal trials.

Purpose of the Study:

  • To examine challenges in neonatal clinical trial compensation.
  • To highlight the inadequacy of existing Indian guidelines for neonates.
  • To propose an improved compensation framework.

Main Methods:

  • Analysis of existing compensation guidelines.
  • Examination of challenges faced in neonatal clinical trial insurance procurement (ProSPoNS trial example).
  • Development of a template for a differential compensation formula.

Main Results:

  • Existing compensation formulas present challenges for neonatal trials.
  • Neonates are a particularly vulnerable population in clinical trials.
  • A birthweight-based differential formula is proposed.

Conclusions:

  • There is a significant need to revise Indian compensation guidelines for neonatal clinical trials.
  • Incorporating factors like birthweight can improve compensation equity.
  • Revised guidelines are essential for protecting vulnerable infant participants.