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Related Experiment Video

Updated: Jun 30, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

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169

THE RELATIONSHIP BETWEEN CIRCULATING IMMUNE CELL PHENOTYPES AND SEPSIS: A MENDELIAN RANDOMIZATION STUDY.

Hongmei Liu1, Hai Liu2, Li Zhou1

  • 1Department of Critical Care Medicine, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.

Shock (Augusta, Ga.)
|March 22, 2024
PubMed
Summary

This study reveals a genetic link between specific immune cell phenotypes and sepsis risk and mortality. Understanding these immune cell roles offers new insights into sepsis development and potential therapeutic targets.

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Area of Science:

  • Immunology
  • Genetics
  • Epidemiology

Background:

  • The role of immune cells in sepsis pathogenesis is not fully understood.
  • Existing research presents conflicting views on immune cell involvement in sepsis.

Purpose of the Study:

  • To systematically investigate the causal relationships between distinct circulating immune cell phenotypes and sepsis susceptibility.
  • To assess the impact of immune cell phenotypes on 28-day sepsis mortality.

Main Methods:

  • Utilized summary-level data from genome-wide association studies (GWASs).
  • Employed two-sample Mendelian randomization (MR) analysis with inverse variance weighting (IVW) as the primary method.
  • Conducted sensitivity analyses using multiple MR methods (weighted median, MR-Egger, mode-based methods) to ensure result robustness.

Main Results:

  • Identified 36 immunophenotypes associated with sepsis risk and 34 with 28-day mortality.
  • After false discovery rate (FDR) correction, four phenotypes (CD45RA- CD4+ %CD4+, HLA DR on HLA DR+ NK, IgD+ CD24+ %B cell, TD DN AC) were significantly linked to sepsis susceptibility.
  • One immunophenotype (CD39 on CD39+ CD8br) showed a significant negative correlation with 28-day mortality post-FDR correction.

Conclusions:

  • This study provides the first genetic evidence for a causal link between specific circulating immune cell phenotypes and sepsis.
  • These findings highlight the critical role of immune cell phenotypes in sepsis development and outcomes.
  • Suggests potential for immune cell profiling in sepsis risk assessment and therapeutic strategies.