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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Stiffness Modulation and Pulsatile Release in Dual Responsive Hydrogels.

Mehak Jain1, Giuseppe Trapani2, Britta Trappmann2,3

  • 1Organic Chemistry Institute and Center for Soft Nanoscience, Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.

Angewandte Chemie (International Ed. in English)
|March 22, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces dual-responsive hydrogels that self-regulate using redox and light stimuli. These smart materials adapt stiffness and control payload release for tunable cell substrates.

Keywords:
Polymer hydrogelsadaptive materialsdrug releaseself-regulation

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Self-regulation in synthetic hydrogels is inspired by nature, enabling adaptation to external triggers.
  • Controlling hydrogel properties like stiffness and stability is crucial for advanced applications.
  • Dual-stimuli responsive materials offer sophisticated control over material behavior.

Purpose of the Study:

  • To develop redox and light dual stimuli responsive hydrogels.
  • To investigate the adaptation of polymer crosslinking networks and hydrogel stability.
  • To explore tunable hydrogels as substrates for cell culture.

Main Methods:

  • Incorporation of redox-responsive disulfide crosslinks and light-responsive ortho-nitrobenzyl moieties into hydrogels.
  • Application of UV irradiation and reducing agents (glutathione) as external stimuli.
  • Monitoring payload release, network adaptation, and changes in hydrogel stiffness.
  • Utilizing hydrogels as substrates for cell culture experiments.

Main Results:

  • UV irradiation induced payload release and increased hydrogel stiffness via S-nitrosylation crosslinking.
  • Glutathione softened the hydrogel network, while UV light stiffened it.
  • Simultaneous stimuli application led to self-regulation and pulsatile payload release.
  • Adaptive stiffness hydrogels were successfully used as tunable substrates for cell lines.

Conclusions:

  • Dual-responsive hydrogels exhibit rapid adaptation of crosslinking networks and tunable stiffness.
  • The developed hydrogels demonstrate controlled and pulsatile payload release.
  • Tunable hydrogel substrates show promise for advanced cell culture applications.