Association Between Peritoneal Carcinomatosis Index (PCI) Assessed by CT and Pathological Parameters and Short-Term Prognosis of Rectal Cancer

Boyuan Zou , Naishun Zhang , Haicheng Gao

Alternative Therapies in Health and Medicine +

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March 22, 2024

View abstract on PubMed

Summary

Preoperative CT-based Peritoneal Carcinomatosis Index (PCI) can predict short-term prognosis in rectal cancer patients undergoing surgery after neoadjuvant therapy. This index helps guide clinical decisions and improve patient outcomes.

Area Of Science

Oncology
Radiology
Surgical Pathology

Background

Rectal cancer management involves complex staging and prognosis assessment.
Neoadjuvant therapy is a common treatment modality for rectal cancer.
Accurate prediction of short-term postoperative outcomes is crucial for patient care.

Purpose Of The Study

To explore the correlation between the CT-based Peritoneal Carcinomatosis Index (CT-PCI) and pathological parameters in rectal cancer.
To investigate the association between preoperative CT-PCI and short-term postoperative prognosis.
To identify CT-PCI as a predictor of postoperative complications.

Main Methods

Retrospective analysis of 198 rectal cancer patients from January 2017 to December 2022.
Classification of patients into normal and low CT-PCI groups based on preoperative CT scans.
Univariate and Multivariable logistic regression, and ROC curve analysis to assess risk factors and predictive value.

Main Results

Significant differences in baseline characteristics and postoperative complications (Clavien-Dindo ≥ Grade II) were observed between CT-PCI groups.
CT-PCI was identified as an independent risk factor for postoperative complications (OR=2.254, P < .05).
The ROC curve showed a high predictive accuracy for CT-PCI in forecasting complications (AUC = 0.854).

Conclusions

Preoperative CT-PCI is a valuable tool for evaluating the short-term prognosis of rectal cancer patients post-neoadjuvant therapy and surgery.
CT-PCI can aid in clinical decision-making and prompt interventions.
Utilizing CT-PCI can enhance short-term patient outcomes in rectal cancer care.