Related Experiment Video
Updated: Jun 30, 2025
07:52
Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
Published on: June 2, 2015
11.9K
Psychedelic Therapy: A Primer for Primary Care Clinicians-Ketamine
Viviana D Evans1, Alejandro Arenas2, Kenneth Shinozuka3,4
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.
American Journal of Therapeutics
|March 22, 2024
Summary
Ketamine offers rapid antidepressant and pain relief, but its effects may wane, requiring repeated doses. This versatile anesthetic shows promise for various psychiatric conditions and pain management.
Area of Science:
- Pharmacology and Psychiatry
- Anesthesiology
Background:
- Ketamine, an arylcyclohexylamine anesthetic, has demonstrated versatility in therapeutic applications.
- Esketamine, its enantiomer, received FDA approval in 2019 for treatment-resistant depression and major depressive disorder with suicidal ideation.
Purpose of the Study:
- To review the therapeutic applications and risks of ketamine.
- To evaluate ketamine's efficacy in treating depression, PTSD, suicidal ideation, and chronic pain.
Main Methods:
- Review of existing research on ketamine's clinical effects and safety profile.
- Analysis of data on ketamine's impact on depression, PTSD, suicidal ideation, and pain management.
Main Results:
- Single intravenous ketamine infusions show rapid antidepressant effects (d = 0.96 at 24 hours).
- Ketamine effectively reduces PTSD and suicidal ideation symptoms and revolutionizes postoperative pain management.
- Potential risks include dose-dependent cognitive effects, liver toxicity, and ketamine cystitis.
Conclusions:
- Ketamine's therapeutic benefits, particularly for depression and suicidal ideation, may require repeated administrations for sustained effects.
- Ketamine presents a significant therapeutic potential for a range of psychiatric conditions and chronic pain.
More Related Videos
05:42Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
Published on: January 7, 2019
31.3K
04:51Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
Published on: April 11, 2019
9.4K
Related Concept Videos
01:22CNS Stimulants: Psychedelic Agents
149
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
149
01:06Altered States of Awareness
184
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
184
01:30Electroconvulsive Therapy
39
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
39
01:29Psychodynamic Therapy
65
Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
65
01:27Hallucinogens and Psychedelics
165
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
165
01:28Drug Therapy
43
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
43