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Related Experiment Video

Updated: Jun 30, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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Brain network hierarchy reorganization in subthreshold depression.

Xiaolong Yin1, Junchao Yang2, Qing Xiang1

  • 1National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Rehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.

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|March 22, 2024
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Summary

Subthreshold depression (StD) is associated with a contracted brain network hierarchy and suppressed cortical gradients. Altered default mode network hierarchy correlates with depression severity, offering insights into StD neural mechanisms.

Keywords:
Default mode networkGradientHierarchySubthreshold depression

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Area of Science:

  • Neuroscience
  • Brain Network Analysis
  • Connectomics

Background:

  • Brain network organization follows a hierarchical principle.
  • The impact of subthreshold depression (StD) on brain network hierarchy remains poorly understood.
  • This study investigates alterations in brain network hierarchy in StD.

Purpose of the Study:

  • To examine changes in brain network hierarchy in patients with StD.
  • To determine the clinical significance of altered network hierarchy in StD.
  • To elucidate the neural mechanisms underlying StD.

Main Methods:

  • Used connectome gradient analysis to assess brain network hierarchy in 43 StD patients and 43 healthy controls.
  • Compared gradient scores in various brain networks between StD patients and controls.
  • Analyzed the relationship between altered gradient scores and clinical characteristics of StD.

Main Results:

  • StD patients exhibited a contracted network hierarchy with suppressed cortical range gradients.
  • Significantly reduced gradient scores in the default mode network (DMN) were observed in StD patients.
  • Reduced DMN gradient scores in specific regions (precuneus, superior temporal gyrus, cingulate cortex) correlated with depression severity.

Conclusions:

  • Brain network hierarchy is altered in StD and significantly correlates with depressive symptoms and severity.
  • These findings enhance understanding of the neural underpinnings of StD.
  • The study highlights the potential of network hierarchy as a biomarker for StD.