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Synthesis of shape-programmable elastomer for a bioresorbable, wireless nerve stimulator
Jun Hyeon Lim1, Won Bae Han2, Tae-Min Jang1
1KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Biosensors & Bioelectronics
|March 22, 2024
Summary
We developed a biodegradable, self-adhesive, shape-transformable polymer (BSS-PLCL) activated by near-physiological temperatures. This material offers exceptional stretchability and tunable dissolution for advanced biomedical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Soft Robotics
Background:
- Shape-transformable materials offer advanced functionalities for soft robotics and biomedical implants.
- Existing materials often have drawbacks like high operating temperatures, rigidity, and biological hazards.
Purpose of the Study:
- To introduce a novel biodegradable, self-adhesive, shape-transformable polymer (BSS-PLCL).
- To demonstrate its potential for biomedical applications through thermal stimulation near physiological temperature.
Main Methods:
- Synthesis and chemical characterization of poly (L-lactide-co-ε-caprolactone) (BSS-PLCL).
- Evaluation of mechanical properties, including stretchability up to 800%.
- Assessment of tunable dissolution behaviors under biological conditions.
Main Results:
- BSS-PLCL exhibits shape transformation triggered by thermal stimulation around 38°C.
- The material demonstrates exceptional stretchability and controllable degradation.
- Successful integration with a bioresorbable electronic system was achieved.
Conclusions:
- BSS-PLCL is a promising biomaterial for advanced applications.
- Its properties are suitable for developing sophisticated soft robotics and biomedical implants.
- The material overcomes limitations of existing shape-transformable polymers.
