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[Studies on the intravenous administration of aspoxicillin in the pediatric field]
Insights
Aspoxicillin (ASPC) shows effective intravenous administration in pediatric patients, achieving good responses in respiratory and urinary tract infections. This antibiotic demonstrated significant bacterial eradication, with minimal side effects, highlighting its utility in pediatric infectious disease treatment.
Area of Science:
- Pharmacology
- Pediatric Infectious Diseases
Context:
- Intravenous administration of antibiotics is crucial for treating severe pediatric infections.
- Understanding the pharmacokinetic and pharmacodynamic properties of new antibiotics is essential for optimizing treatment regimens.
Purpose:
- To evaluate the safety and efficacy of intravenous aspoxicillin (ASPC) in pediatric patients.
- To determine the pharmacokinetic profile, including serum concentrations, half-life, and urinary excretion of ASPC.
- To assess the clinical response and bacterial eradication rates in children with acute respiratory tract and urinary tract infections.
Summary:
- Aspoxicillin (ASPC) demonstrated dose-dependent peak serum concentrations (15.6-84.0 µg/ml) after a 1-hour drip infusion (10-30 mg/kg).
- The drug exhibited a half-life of 0.78-1.67 hours, with measurable serum concentrations up to 6 hours post-administration and a urinary excretion rate of 44.1-78.6% within 6 hours.
- Treatment of 24 pediatric patients with acute respiratory tract and urinary tract infections using ASPC (50-107 mg/kg/day for 5-15 days) resulted in a 100% good response rate, with eradication of common pathogens like S. pyogenes, S. viridans, E. coli, and H. influenzae, but not P. aeruginosa.
Impact:
- Aspoxicillin (ASPC) proves to be a valuable therapeutic option for managing bacterial infections in the pediatric population.
- The study supports the use of ASPC as an effective and safe antibiotic for pediatric infectious diseases, with a favorable safety profile and high efficacy rates.
Abstract:
Fundamental and clinical studies were made on the intravenous administration of aspoxicillin (ASPC) in pediatric field and the following results were obtained. The peak serum concentrations of 15.6-84.0 micrograms/ml were seen immediately after a 1-hour drip infusion of 10-30 mg/kg, there being seen a clear dose response. The half-life was 0.78-1.67 hours and the measurable concentrations were detected in the serum up to 6 hours after administration. The urinary excretion rate was 44.1-78.6% up to 6 hours after drip infusion. Twenty-four patients with acute respiratory tract infection (21 cases), urinary tract infection (3 cases) were treated with ASPC by drip infusion of 50-107 mg/kg/day for 5-15 days and resulted in 100% of good response. S. pyogenes, S. viridans, E. coli, H. influenzae and P. aeruginosa were isolated form the culture of sputum or urine in the patients, and they were all eradicated by treatment with ASPC except P. aeruginosa. No side effects were observed except the elevation of GOT and GPT in 1 case. From the above results, it is concluded that ASPC is one of useful drug for treatment of infections in pediatric field.