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Related Concept Videos

Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
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Barrett Esophagus-II: Clinical Manifestations and Management01:21

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
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Behavior Therapy01:22

Behavior Therapy

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Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
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Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

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Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
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Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists01:28

Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists

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Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
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Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
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Related Experiment Video

Updated: Jun 30, 2025

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
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Behavioral Therapy for Functional Heartburn: Recommendation Statements.

Livia Guadagnoli1, Rena Yadlapati2, John Pandolfino3

  • 1Laboratory for Brain-Gut Axis Studies (LaBGAS), Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|March 22, 2024
PubMed
Summary
This summary is machine-generated.

Expert recommendations for brain-gut behavior therapies (BGBT) in functional heartburn are established. Gut-directed hypnotherapy or cognitive behavioral therapy are appropriate initial treatments, with neuromodulation for non-response.

Keywords:
Behavioral MedicineEsophageal DisorderHealth-Related Quality of LifeHeartburnPsychogastroenterology

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Area of Science:

  • Gastroenterology
  • Psychology
  • Behavioral Medicine

Background:

  • Functional heartburn lacks specific recommendations for behavioral interventions.
  • Brain-gut behavior therapies (BGBT) show promise but require defined treatment pathways.
  • Expert consensus is needed for candidacy, selection, and management of non-response in BGBT for functional heartburn.

Purpose of the Study:

  • To establish expert-based recommendations for behavioral treatment in functional heartburn.
  • To define candidacy criteria and initial treatment selection for BGBT.
  • To outline strategies for managing treatment non-response to BGBT.

Main Methods:

  • The RAND/UCLA Appropriateness Method was employed.
  • A 15-member expert panel (gastrointestinal psychologists and esophageal specialists) participated.
  • Two ranking periods assessed the appropriateness of various BGBT-related statements.

Main Results:

  • Recommendations were established for psychosocial assessment, candidacy criteria, and treatment selection.
  • Gut-directed hypnotherapy and cognitive behavioral therapy were deemed appropriate initial BGBT.
  • Neuromodulation and/or additional BGBT were recommended for non-responders.

Conclusions:

  • Gut-directed hypnotherapy and cognitive behavioral therapy are recommended for functional heartburn.
  • Treatment selection depends on clinical indication, gut-brain targets, and modality preference.
  • Pre-therapy psychosocial evaluation and candidacy assessment are crucial for BGBT referral.