Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

582
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
582
T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

7.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.4K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

984
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
984
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

721
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
721

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relapse risk of lupus-related serositis according to immunosuppressive therapy: a national real-world study.

RMD open·2026
Same author

Corrigendum to "Investigation of the binding mode of clobenprobit at CXCR4 and development of novel anti-inflammatory compounds with enhanced activity and minimal antagonist effects" [Molecular Pharmacology 107 (2025) 100055].

Molecular pharmacology·2025
Same author

Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice.

EMBO molecular medicine·2025
Same author

Investigation of the binding mode of clobenprobit at CXCR4 and development of novel anti-inflammatory compounds with enhanced activity and minimal antagonist effects.

Molecular pharmacology·2025
Same author

Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis.

The Journal of pathology·2025
Same author

Editorial: Community series in primary immunodeficiencies worldwide, volume II.

Frontiers in immunology·2025

Related Experiment Video

Updated: Jun 30, 2025

Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production
08:22

Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production

Published on: May 31, 2020

5.1K

CXCR4: from B-cell development to B cell-mediated diseases.

Stéphane Giorgiutti1,2,3, Julien Rottura2, Anne-Sophie Korganow4,2,3

  • 1Department of Clinical Immunology and Internal Medicine, National Reference Center for Systemic Autoimmune Diseases (CNR RESO), Tertiary Center for Primary Immunodeficiency, Strasbourg University Hospital, Strasbourg, France Stephane.Giorgiutti@chru-strasbourg.fr.

Life Science Alliance
|March 22, 2024
PubMed
Summary

The C-X-C chemokine receptor type 4 (CXCR4) is crucial for B-cell development and function. Targeting CXCR4 offers potential therapeutic strategies for B-cell disorders like immunodeficiencies and autoimmune diseases.

More Related Videos

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

5.3K
A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
06:56

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

13.7K

Related Experiment Videos

Last Updated: Jun 30, 2025

Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production
08:22

Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production

Published on: May 31, 2020

5.1K
Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

5.3K
A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
06:56

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

13.7K

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Chemokine receptors, including C-X-C chemokine receptor type 4 (CXCR4), are G protein-coupled receptors vital for immune cell function.
  • CXCR4 is broadly expressed on hematopoietic and immune cells, mediating leukocyte trafficking via its ligand CXCL12.
  • CXCR4 plays a critical role throughout B-cell development, from progenitor stages to antibody-secreting cell differentiation.

Purpose of the Study:

  • To review the multifaceted roles of CXCR4 in B-cell development and homeostasis.
  • To explore the involvement of CXCR4 in various B-cell-mediated disorders.
  • To discuss the therapeutic potential of targeting CXCR4 for treating B-cell-related diseases.

Main Methods:

  • Literature review focusing on CXCR4's function in B-cell biology.
  • Analysis of CXCR4's involvement in central tolerance and immune cell trafficking.
  • Examination of the link between CXCR4 and pathologies such as WHIM syndrome and systemic lupus erythematosus.

Main Results:

  • CXCR4 is essential for normal B-cell development, including central tolerance.
  • Dysregulation of CXCR4 is implicated in immunodeficiencies (e.g., WHIM syndrome) and autoimmune diseases (e.g., SLE).
  • Novel therapeutic strategies targeting CXCR4 pockets show promise for modulating B-cell responses.

Conclusions:

  • CXCR4 is a key regulator of B-cell development and immunity.
  • Targeting CXCR4 presents a promising avenue for novel therapeutics in B-cell disorders.
  • Further research into CXCR4 modulation could lead to innovative treatments for immune-related conditions.