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The relationship between C-reactive protein/albumin ratio and mortality in hypertensive patients: A national cohort

Rongting Zhang1, Yani Wang2, Lihua Liao2

  • 1Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|March 22, 2024
PubMed

Insights

Elevated C-reactive protein to albumin ratio (CAR) in hypertension patients indicates a higher risk of mortality. This inflammatory marker can aid in risk stratification for better hypertension management.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Biomarkers
  • Hypertension Research

Background:

  • Inflammation's role in hypertension prognosis is under investigation.
  • C-reactive protein to albumin ratio (CAR) is a novel inflammatory marker.
  • The association between CAR and mortality in hypertensive individuals requires further study.

Purpose of the Study:

  • To investigate the relationship between the C-reactive protein to albumin ratio (CAR) and mortality risk in patients with hypertension.
  • To determine if CAR can serve as a prognostic indicator in hypertensive individuals.

Main Methods:

  • Analysis of 9561 hypertensive patients.
  • Calculation of C-reactive protein to albumin ratio (CAR).
  • Kaplan-Meier survival analysis and multivariable Cox regression models were used.

Main Results:

  • Higher baseline CAR levels were associated with increased all-cause mortality.
  • Patients in the highest CAR tertile had a 60% increased risk of mortality (HR, 1.60 [95%CI, 1.23-2.09]).
  • P-value < 0.001 indicated statistical significance.

Conclusions:

  • Elevated CAR is linked to a higher risk of all-cause mortality in hypertensive patients.
  • CAR may be a valuable tool for risk stratification in hypertension.
  • Utilizing CAR can help optimize follow-up and treatment strategies for hypertensive individuals.
Abstract

Keywords:
C-reactive protein/albumin ratioHypertensionInflammationMortality

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