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The relationship between C-reactive protein/albumin ratio and mortality in hypertensive patients: A national cohort
Rongting Zhang1, Yani Wang2, Lihua Liao2
1Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Elevated C-reactive protein to albumin ratio (CAR) in hypertension patients indicates a higher risk of mortality. This inflammatory marker can aid in risk stratification for better hypertension management.
Area of Science:
- Cardiovascular Medicine
- Inflammation Biomarkers
- Hypertension Research
Background:
- Inflammation's role in hypertension prognosis is under investigation.
- C-reactive protein to albumin ratio (CAR) is a novel inflammatory marker.
- The association between CAR and mortality in hypertensive individuals requires further study.
Purpose of the Study:
- To investigate the relationship between the C-reactive protein to albumin ratio (CAR) and mortality risk in patients with hypertension.
- To determine if CAR can serve as a prognostic indicator in hypertensive individuals.
Main Methods:
- Analysis of 9561 hypertensive patients.
- Calculation of C-reactive protein to albumin ratio (CAR).
- Kaplan-Meier survival analysis and multivariable Cox regression models were used.
Main Results:
- Higher baseline CAR levels were associated with increased all-cause mortality.
- Patients in the highest CAR tertile had a 60% increased risk of mortality (HR, 1.60 [95%CI, 1.23-2.09]).
- P-value < 0.001 indicated statistical significance.
Conclusions:
- Elevated CAR is linked to a higher risk of all-cause mortality in hypertensive patients.
- CAR may be a valuable tool for risk stratification in hypertension.
- Utilizing CAR can help optimize follow-up and treatment strategies for hypertensive individuals.
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