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Related Experiment Video

Updated: Jun 30, 2025

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FAPI-PET in Cardiovascular Disease.

Takahiro Higuchi1, Sebastian E Serfling2, David M Leistner3

  • 1Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg; Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Seminars in Nuclear Medicine
|March 22, 2024
PubMed
Summary
This summary is machine-generated.

Positron emission tomography (PET) probes targeting fibroblasts are increasingly used in cardiovascular medicine. This review covers current evidence and future applications of fibroblast-targeting PET in cardiovascular diseases and the cardiorenal axis.

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Area of Science:

  • Cardiovascular Medicine
  • Oncology
  • Radiochemistry

Background:

  • Fibroblast-targeting PET probes are established in oncology.
  • Their application is expanding into cardiovascular medicine, including myocardial infarction, aortic stenosis, and atherosclerosis.
  • Fibroblasts play a critical role in cardiovascular pathophysiology.

Purpose of the Study:

  • To provide an overview of fibroblast-targeting PET in cardiovascular disease.
  • To summarize translational and clinical evidence for these probes.
  • To discuss future applications, including the cardiorenal axis.

Main Methods:

  • Review of existing literature on fibroblast-targeting PET in cardiovascular applications.
  • Analysis of translational studies (preclinical) and clinical trial data.
  • Discussion of emerging research and future directions.

Main Results:

  • Fibroblast-targeting PET shows promise for non-invasively assessing cardiovascular conditions.
  • Evidence supports its use in myocardial infarction, aortic stenosis, and atherosclerosis.
  • Translational and clinical data are accumulating, demonstrating feasibility and potential.

Conclusions:

  • Fibroblast-targeting PET is a valuable tool for cardiovascular disease management and research.
  • Future applications may extend to understanding complex organ interactions, such as the cardiorenal axis.
  • Continued research is warranted to fully realize the clinical potential of these probes.