Medication-related osteonecrosis of the jaw in a paediatric patient taking denosumab: a case report
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Published on: June 8, 2014
Dominic Innes-Taylor1, Vicky Adams2
1Dental Core Trainee 2, Oral Surgery and Oral Medicine, School of Dentistry, Belfast, UK. dominic.innestaylor@belfasttrust.hscni.net.
Abstract:
Medication-related osteonecrosis of the jaw (MRONJ) is a known complication of antiresorptive and anti-angiogenic therapies in adults. Increasingly, these drugs are being prescribed for children with a variety of conditions, such as osteogenesis imperfecta and cancers of the bone. Review of the literature, however, reveals no reported paediatric MRONJ cases to date. We present such a case in a nine-year-old female patient with a vertebral aneurysmal bone cyst, who received dental extractions subsequent to denosumab therapy.
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