Prognostic Role of Preoperative Chemotherapy in Liver-Limited Metastasis from Gastric Cancer

Yuki Hirose ^1,2, Masaki Aizawa ³, Hiroshi Yabusaki ³

⁰Department of Digestive Surgery, Niigata Cancer Center Hospital, Niigata, Japan. y-hirose@med.niigata-u.ac.jp.

Annals of Surgical Oncology +

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March 23, 2024

View abstract on PubMed

Summary

Preoperative chemotherapy improves survival for gastric cancer patients with liver metastases undergoing surgery. This approach is recommended, and its effectiveness helps guide surgical decisions for liver-limited metastasis.

Area Of Science

Surgical Oncology
Gastrointestinal Oncology
Medical Oncology

Background

Investigating the prognostic significance of preoperative chemotherapy in gastric cancer (GC) patients undergoing hepatectomy for liver-limited metastasis (LLM).
Assessing the impact of neoadjuvant therapy on outcomes for patients with resectable LLM from GC.

Purpose Of The Study

To evaluate the role of preoperative chemotherapy in improving overall survival (OS) for patients with LLM from GC.
To determine if preoperative chemotherapy is an independent prognostic factor for hepatectomy in GC patients with LLM.

Main Methods

Retrospective analysis of 52 patients with R0 or R1 resection for synchronous or metachronous LLM from GC.
Comparison of outcomes between patients receiving preoperative chemotherapy (PC group) and those undergoing upfront surgery (US group).

Main Results

The PC group demonstrated significantly longer overall survival (5-year OS: 47.6% vs. 24.8%, p=0.041).
Preoperative chemotherapy was an independent favorable prognostic factor (HR: 0.445, p=0.036).
Partial response to chemotherapy correlated with improved OS, and the PC group had higher rates of solitary recurrence and re-resection.

Conclusions

Preoperative chemotherapy is a recommended treatment for patients with LLM from GC.
Evaluating chemotherapy response aids in determining surgical indications for LLM in GC.

Keywords:

Liver metastasis from gastric cancer Preoperative chemotherapy RECIST Upfront surgery