Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pitch as a Shared Code for Music and Speech: Behavioral and Neural Evidence From Stroke Patients.

Brain and behavior·2026

Same author

Network-level disconnectivity tracks poststroke depressive symptom improvement.

Psychiatry and clinical neurosciences·2026

Same author

Mapping the role of sensation in arm function after stroke-from somatosensation to sensorimotor function, arm use, and participation: a scoping review.

Disability and rehabilitation·2026

Same author

Author's response to 'Quantitative clinical assessment of wrist proprioception with stroke survivors'.

Clinical rehabilitation·2026

Same author

Optimising communication function in primary brain tumour: a randomised controlled trial of CanCommunicate.

Disability and rehabilitation·2026

Same author

Quantitative clinical assessment of wrist proprioception with stroke survivors.

Clinical rehabilitation·2026

Same journal

Benchmarking fMRI Denoising Pipelines.

Human brain mapping·2026

Same journal

Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.

Human brain mapping·2026

Same journal

Intrinsic Functional Architecture Reflects Individual Differences in Passive Working Memory: An Exploratory Resting-State fMRI Study.

Human brain mapping·2026

Same journal

Symptom Overlap and Neurobiological Similarities Between Posttraumatic Stress Disorder and Tinnitus.

Human brain mapping·2026

Same journal

Test-Retest Reliability of Sensorimotor Activity Measured With Spinal Cord fMRI.

Human brain mapping·2026

Same journal

The Human Visual Claustrum Responses to Physical Stimulus Properties and Subjective Content During Movie Viewing.

Human brain mapping·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 30, 2025

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

Structural brain networks correlating with poststroke cognition.

Sonia L E Brownsett^1,2,3, Leeanne M Carey^4,5, David Copland^1,2,3

¹Centre of Research Excellence in Aphasia Recovery and Rehabilitation, La Trobe University, Melbourne, Victoria, Australia.

Human Brain Mapping

|March 23, 2024

Summary

This summary is machine-generated.

Structural brain connectivity, not focal lesions, predicts cognitive recovery after stroke. White matter tracts like the cingulum and corpus callosum are key biomarkers for cognitive function assessed by MoCA and MMSE.

Keywords:

MMSE MoCA cognition connectometry stroke white matter

More Related Videos

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

Related Experiment Videos

Last Updated: Jun 30, 2025

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Published on: December 28, 2014

Area of Science:

Neuroscience
Neurology
Radiology

Background:

Cognitive deficits are common after stroke, impacting recovery.
Understanding neurobiological markers for post-stroke cognition is limited.
Focal lesions and structural connectivity influence cognitive function.

Purpose of the Study:

Investigate the impact of focal lesions and structural connectivity on post-stroke cognition.
Identify neurobiological biomarkers predicting cognitive recovery.
Examine cross-sectional and longitudinal relationships between brain structure and cognition.

Main Methods:

Longitudinal observational study of 62 stroke patients.
Advanced brain imaging (multi-shell diffusion-weighted MRI) and cognitive assessments (MoCA, MMSE) at 3 and 12 months.
Voxel-based lesion-symptom mapping and correlational tractography.

Main Results:

Voxel-based lesion-symptom mapping showed no significant findings.
Correlational tractography revealed positive associations between MoCA/MMSE scores and bilateral cingulum and corpus callosum.
These associations were observed cross-sectionally at 3 months and longitudinally.

Conclusions:

A consistent structural connectome, rather than focal lesions, underpins cognitive screening tool performance (MoCA, MMSE) post-stroke.
Clinicians should consider cognitive decline when lesions affect specific white matter tracts.
Findings encourage novel diagnostic approaches for cognitive decline regardless of stroke etiology.