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Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

87
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

357
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
357

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Related Experiment Video

Updated: Jun 30, 2025

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Identification of Potential Hub Genes Related to Acute Pancreatitis and Chronic Pancreatitis via Integrated

Lu Yuan1, Yiyuan Liu1, Lingyan Fan2

  • 1School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.

Molecular Biotechnology
|March 23, 2024
PubMed
Summary

This study reveals key genes and the Th17 signaling pathway driving the progression from acute pancreatitis to chronic pancreatitis. Findings offer new therapeutic targets for pancreatitis treatment.

Keywords:
Acute pancreatitisChronic pancreatitisHelper T-cell factor signaling pathwayHub genes

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Gastroenterology

Background:

  • Acute pancreatitis (AP) and chronic pancreatitis (CP) are typically viewed as distinct conditions.
  • Emerging evidence suggests a potential link between AP and CP, but the underlying mechanisms remain unclear.

Purpose of the Study:

  • To elucidate the critical signaling pathways and genes involved in the progression from AP to CP using bioinformatics analysis.
  • To identify potential therapeutic targets for pancreatitis.

Main Methods:

  • Bioinformatic analysis of murine transcriptomes.
  • Differential gene expression analysis using R and R/Bioconductor.
  • Gene network analysis (STRING), functional enrichment (Metascape), and hub gene screening (Cytoscape).
  • Validation of hub gene mRNA levels via qRT-PCR in AP and CP mouse models.

Main Results:

  • Identified key hub genes: Jun, Cd44, Epcam, Spp1, Anxa2, Hsp90aa1, and Cd9, crucial for AP to CP progression.
  • These genes are significantly enriched in the T-helper 17 (Th17) signaling pathway.
  • Up-regulation of these hub genes was confirmed in both AP and CP mouse models.

Conclusions:

  • The Th17 signaling pathway plays a significant role in the transition from AP to CP.
  • The identified hub genes (Jun, Cd44, Epcam, Spp1, Anxa2, Hsp90aa1, Cd9) are critical drivers of pancreatitis progression.
  • This research provides molecular insights and potential therapeutic targets for pancreatitis.