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Characterization of Gold-Enhanced Titania: Boosting Cell Proliferation and Combating Bacterial Infestation
Touseef Amna1, M Shamshi Hassan2, Jari S Algethami3,4
1Department of Biology, Faculty of Science, Al-Baha University, P.O. Box 1988, 65799, Al-Baha, Saudi Arabia. touseefamna@gmail.com.
Gold-enhanced titania nanorods show strong antimicrobial properties against E. coli. These novel nanomaterials also demonstrate good biocompatibility, indicating potential for tissue engineering and biomedical applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Materials Chemistry
Background:
- Implant-related infections pose significant health risks.
- Novel materials with multifunctional properties are needed.
- Gold-enhanced titania nanorods offer potential solutions.
Purpose of the Study:
- To synthesize gold-enhanced titania nanorods using electrospinning.
- To investigate their effects on muscle precursor cells (C2C12).
- To evaluate their antimicrobial efficacy and cytotoxicity.
Main Methods:
- Gold nanoparticles were attached to titania nanorods.
- Characterization using XRD, SEM, EDX, and TEM.
- Antimicrobial tests against Escherichia coli.
- In vitro cytotoxicity and proliferation assays on C2C12 cells.
Main Results:
- Gold-enhanced titania nanorods showed superior antimicrobial activity compared to pure titania.
- Cell viability was dependent on the concentration and exposure time of the nanorods.
- The materials exhibited good biocompatibility with C2C12 cells.
Conclusions:
- Gold-adorned titania nanorods are promising for developing antimicrobial materials.
- Potential applications in medical and biomedical fields, including tissue engineering.
- The synthesized nanorods are highly biocompatible and adaptable.
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