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Updated: Jun 30, 2025
Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
Published on: August 19, 2014
Assessment for 11q and other chromosomal aberrations in large B-cell/high-grade B cell lymphomas of germinal center
Chia-Chen Ho1, Kikkeri Naresh1, Yajuan Liu2
1Department of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific St. Box 357470, Seattle, WA, USA; Fred Hutchinson Cancer Center, Clinical Research Division, 1100 Fairview Avenue N., Seattle, WA 98109, USA.
Abstract:
The WHO classifications of hematolymphoid malignancies have recognized several distinct entities within the large B cell lymphomas, including the more recently described high-grade B cell lymphoma with 11q aberration (HGBCL-11q). We utilized genomic array to assess for chromosome 11q abnormalities in a broad set of aggressive B cell lymphomas from 27 patients with a focus on younger adults. The findings suggest more frequent alterations of 11q in diffuse large B cell lymphoma (DLBCL)/HGBCL-GC BCL2-, in comparison to cases of Burkitt lymphoma (BL) or DLBCL-GC BCL2+, and confirm a low genomic complexity score of BL. Variability identified in patterns of 11q alterations suggests genomic array studies may afford value over FISH testing as we continue to understand HGBCL-11q as a distinct entity, and interrogate cases of DLBCL/HGBCL-GC BCL2-.
