Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metagenomic insights into the mechanisms of heteroatom-doped, iron-loaded biochar in enhancing anaerobic digestion of waste activated sludge.

Bioresource technology·2026
Same author

MolPy: A Large Language Model-Friendly Toolkit for Reactive Topology Editing in Polymer Simulations.

Journal of chemical information and modeling·2026
Same author

A biomimetic nano-platelet as an antidote for dual antiplatelet therapy-induced bleeding.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Low-dose esketamine for postoperative fatigue after gynecological laparoscopic surgery: a randomized controlled trial.

BMC anesthesiology·2026
Same author

Ecological barrier crossing strategies in longitudinal migrants: a case study of Mongolian gulls (Larus mongolicus) distributed in East Asia.

Movement ecology·2026
Same author

GATA2 promotes hepatitis B virus-associated hepatocellular carcinoma development by regulating AURKA.

Archives of microbiology·2026

Related Experiment Video

Updated: Jun 30, 2025

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.3K

Elucidating immune cell dynamics in chronic lung allograft dysfunction: A comprehensive single-cell transcriptomic

Yu Bai1, Liang Di1, Wanying Liu1

  • 1Department of Thoracic Surgery, The Second Hospital of Dalian Medical University, Dalian, China.

Computers in Biology and Medicine
|March 23, 2024
PubMed
Summary
This summary is machine-generated.

Chronic Lung Allograft Dysfunction (CLAD) involves complex immune cell interactions. This study reveals T cells play a key role in CLAD, offering new therapeutic targets for lung transplant recipients.

Keywords:
Convolutional neural networkDeep learningEnrichment analysisLungSingle-cell

More Related Videos

Isolation of Live Myeloid and Epithelial Cell Populations from the Mouse Lung
06:02

Isolation of Live Myeloid and Epithelial Cell Populations from the Mouse Lung

Published on: January 31, 2025

565
Author Spotlight: Advancing Lung Transplant Immunology Through Intravital Imaging
04:16

Author Spotlight: Advancing Lung Transplant Immunology Through Intravital Imaging

Published on: April 19, 2024

984

Related Experiment Videos

Last Updated: Jun 30, 2025

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.3K
Isolation of Live Myeloid and Epithelial Cell Populations from the Mouse Lung
06:02

Isolation of Live Myeloid and Epithelial Cell Populations from the Mouse Lung

Published on: January 31, 2025

565
Author Spotlight: Advancing Lung Transplant Immunology Through Intravital Imaging
04:16

Author Spotlight: Advancing Lung Transplant Immunology Through Intravital Imaging

Published on: April 19, 2024

984

Area of Science:

  • Immunology
  • Transplantation Science
  • Genomics

Background:

  • Chronic Lung Allograft Dysfunction (CLAD) significantly impacts lung transplant recipient survival.
  • Current immunosuppressive treatments for CLAD have limited efficacy, highlighting knowledge gaps in its immunological underpinnings.
  • A deeper understanding of immune cell dynamics is crucial for developing effective CLAD interventions.

Purpose of the Study:

  • To comprehensively analyze the immune environment in Chronic Lung Allograft Dysfunction (CLAD).
  • To identify specific immune cell populations and molecular pathways involved in CLAD pathogenesis.
  • To uncover potential therapeutic targets for mitigating CLAD progression.

Main Methods:

  • Gene expression profiling of key immune cells including T cells, NK cells, B cells, macrophages, and monocytes.
  • Comparative analysis of immune cell landscapes between CLAD patients and healthy controls.
  • Pathway enrichment analysis to identify dysregulated molecular mechanisms.

Main Results:

  • A distinct immunological landscape was identified in CLAD compared to healthy controls.
  • Significant heterogeneity was observed within immune cell populations in CLAD.
  • T cells were identified as central players in CLAD pathophysiology, orchestrating amplified immune responses.
  • Specific overactive and suppressed molecular pathways implicated in CLAD were revealed.

Conclusions:

  • The study provides a detailed cellular and molecular profile of the immune environment in CLAD.
  • Findings underscore the critical role of T cells and amplified immune networks in CLAD pathogenesis.
  • This research establishes a foundation for developing targeted immunotherapies for lung transplant recipients experiencing CLAD.