Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Potential of Rehabilitation to Amplify Experience-Induced Myelin Plasticity and Remyelination in Multiple Sclerosis: A Narrative Review.

Current neurology and neuroscience reports·2026
Same author

Beyond chronological age: biological aging and its relevance for motor and cognitive function in multiple sclerosis.

Neurodegenerative disease management·2026
Same author

Does Depressed Mood Affect Accuracy of Perceptions of Cognitive Function in Multiple Sclerosis? The Role of Momentary Depressive Symptoms in the Correspondence Between Subjective and Objective Cognition in Multiple Sclerosis.

Archives of physical medicine and rehabilitation·2026
Same author

Accelerated Brain Aging Identifies Functional Vulnerability Beyond Chronological Age in Multiple Sclerosis.

Sensors (Basel, Switzerland)·2026
Same author

Examining the Impact of Perceived and Objective Cognitive Function on Social Participation in Individuals With Multiple Sclerosis.

Archives of physical medicine and rehabilitation·2026
Same author

Moving the Movement System Forward in Neurologic Physical Therapy.

Journal of neurologic physical therapy : JNPT·2026

Related Experiment Video

Updated: Jun 30, 2025

Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury
07:28

Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

Published on: March 24, 2023

2.8K

Backwards walking speed reserve in persons with multiple sclerosis.

Patrick G Monaghan1, Michael VanNostrand1, Nora E Fritz2

  • 1Department of Health Care Sciences, Wayne State University, Detroit, MI, United States.

Multiple Sclerosis and Related Disorders
|March 23, 2024
PubMed
Summary

Backward walking speed reserve (BW-WSR) in multiple sclerosis (MS) patients did not show a distinct advantage over forward walking measures for assessing functional mobility or fall risk. Further research is needed to identify the most sensitive clinical assessments for persons with MS.

Keywords:
AssessmentBackward walkingFallsMobilityMultiple sclerosis

More Related Videos

Home-Based Monitor for Gait and Activity Analysis
07:24

Home-Based Monitor for Gait and Activity Analysis

Published on: August 8, 2019

6.7K
Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb
08:24

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

Published on: August 30, 2016

10.2K

Related Experiment Videos

Last Updated: Jun 30, 2025

Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury
07:28

Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

Published on: March 24, 2023

2.8K
Home-Based Monitor for Gait and Activity Analysis
07:24

Home-Based Monitor for Gait and Activity Analysis

Published on: August 8, 2019

6.7K
Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb
08:24

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

Published on: August 30, 2016

10.2K

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Biomedical Engineering

Background:

  • Gait speed reduction is prevalent in persons with Multiple Sclerosis (PwMS), correlating with increased fall risk.
  • Walking Speed Reserve (WSR) assesses the ability to increase gait speed on demand.
  • Backward walking is a sensitive indicator of fall risk in PwMS, but its reserve (BW-WSR) has not been studied for functional mobility or cognitive associations.

Purpose of the Study:

  • To investigate the clinical utility of Backward Walking Speed Reserve (BW-WSR) in PwMS.
  • To examine the relationship between BW-WSR and functional mobility, cognitive function, and prospective falls.
  • To compare BW-WSR with Forward Walking Speed Reserve (FW-WSR) and other established measures.

Main Methods:

  • 23 PwMS completed forward (FW) and backward (BW) walking trials at preferred (PWS) and maximal (MWS) speeds.
  • Calculated FW-WSR (MWS-PWS forward) and BW-WSR (MWS-PWS backward).
  • Correlated WSR measures with functional mobility (Timed Up-and-Go), cognitive tests (SDMT, BVMT-R, CVLT, TMT A/B), and prospective falls.

Main Results:

  • Lower BW-WSR correlated with greater MS disease severity and poorer performance in walking, balance, and cognitive tests (information processing speed, attention).
  • FW-WSR demonstrated similar associations.
  • Neither FW-WSR nor BW-WSR predicted prospective falls in this cohort.

Conclusions:

  • BW-WSR did not provide a significant advantage over FW-WSR or preferred/maximal walking speeds for assessing PwMS.
  • Identifying sensitive clinical measures for functional mobility and fall risk in PwMS remains critical.
  • This study offers insights into novel functional mobility assessments for PwMS.