Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk...

Area of Science:

• Environmental Chemistry
• Toxicology
• Public Health

Background:

• Increasing chemical burden on environment and human populations requires updated risk assessment strategies.
• A 'One Health' perspective is crucial for understanding chemical risks across ecosystems, food, and humans.
• Current surveillance methods need enhancement to address known, emerging, and future chemical concerns.

Purpose of the Study:

• To outline needs and recommendations for next-generation chemical risk assessment within the European Partnership for Assessment of Risks from Chemicals (PARC) project.
• To leverage innovative methodologies for improved chemical surveillance and identification.
• To support public policies for exposure mitigation and sustainable chemical design.

Main Methods:

• Integration of less-conventional sampling strategies.
• Application of full-scan, high-resolution mass spectrometry (HRMS).
• Utilization of effect-directed analysis (EDA) in monitoring programs.

Main Results:

• These methods enhance the screening and identification of a wider range of chemicals.
• Potential to improve early warning systems for chemical risks.
• Supports the development of next-generation chemical risk assessment frameworks.

Conclusions:

• Innovative methodologies are key to advancing chemical risk assessment.
• Enhanced monitoring is vital for protecting ecosystem and human health from chemical exposures.
• PARC project recommendations aim to foster safer and sustainable chemical management strategies.