Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

1.5K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.5K
Lipid Absorption01:24

Lipid Absorption

465
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
465
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

38
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
38
Lipid Digestion01:06

Lipid Digestion

91.6K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
91.6K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

104.4K
Overview
104.4K
What are Lipids?01:38

What are Lipids?

198.1K
Overview
198.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting of CH25H to boost p62-dependent autophagic degradation of α-synuclein in cell and mouse models of Parkinson's disease.

Science translational medicine·2026
Same author

Novel treatments for Parkinson's disease.

Chinese medical journal·2026
Same author

Pan-immune inflammation value and neutrophil-to-albumin ratio predict hemorrhagic transformation after intravenous thrombolysis in acute ischemic stroke: a dual-center cohort study.

Frontiers in nutrition·2026
Same author

Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

Environmental health perspectives·2026
Same author

Association of remnant cholesterol and cholesterol, high-density lipoprotein, and glucose index with unfavorable outcomes after intravenous thrombolysis in acute ischemic stroke: a dual-center cohort study.

Frontiers in immunology·2026
Same author

The efficacy and safety of precision repetitive transcranial magnetic stimulation in alleviating motor symptoms in Parkinson's disease (PRESS-PD): a randomized, double-blind, multicenter, placebo-controlled trial.

Trials·2026

Related Experiment Video

Updated: Jun 30, 2025

Defining Substrate Specificities for Lipase and Phospholipase Candidates
08:59

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

15.0K

A unified model for regulating lipoprotein lipase activity.

Ren Zhang1, Kezhong Zhang1

  • 1Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Trends in Endocrinology and Metabolism: TEM
|March 23, 2024
PubMed
Summary

Lipoprotein lipase (LPL) regulates triglyceride (TG) metabolism. Key proteins like ANGPTL3, 4, and 8 form a regulatory model influencing TG distribution and energy homeostasis.

Keywords:
ANGPTL3ANGPTL4ANGPTL8APOA5APOC2APOC3CREBHlipoprotein lipase

More Related Videos

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

2.8K
Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

11.2K

Related Experiment Videos

Last Updated: Jun 30, 2025

Defining Substrate Specificities for Lipase and Phospholipase Candidates
08:59

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

15.0K
Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

2.8K
Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

11.2K

Area of Science:

  • Metabolic regulation
  • Lipid metabolism
  • Energy homeostasis

Background:

  • Triglyceride (TG) tissue distribution, storage, and utilization are crucial for energy homeostasis.
  • Lipoprotein lipase (LPL) is central to regulating these TG processes.
  • Several proteins, including angiopoietin-like proteins (ANGPTLs) and apolipoproteins, are known regulators of LPL activity.

Purpose of the Study:

  • To review the intricate mechanisms regulating LPL activity.
  • To present a unified model for LPL regulation by ANGPTL3, ANGPTL4, and ANGPTL8.
  • To offer insights into TG metabolism, metabolic diseases, and potential therapeutics.

Main Methods:

  • Literature review of LPL regulation mechanisms.
  • Analysis of the roles of ANGPTL3, ANGPTL4, ANGPTL8, apolipoproteins (APOA5, APOC3, APOC2), and CREBH.
  • Integration of findings into the ANGPTL3-4-8 model.

Main Results:

  • ANGPTL3, ANGPTL4, and ANGPTL8 form a regulatory complex influencing LPL activity.
  • ANGPTL8 acts as a molecular switch, modulating ANGPTL3 and ANGPTL4 interactions.
  • The ANGPTL3-4-8 model explains TG partitioning between white adipose tissue and oxidative tissues during feeding and fasting.

Conclusions:

  • The ANGPTL3-4-8 model provides a unified perspective on LPL regulation.
  • Understanding these mechanisms offers insights into TG metabolism and related metabolic diseases.
  • This regulatory network presents potential therapeutic targets for metabolic disorders.