Related Experiment Video

Updated: Jun 30, 2025

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

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Shared and differing functional connectivity abnormalities of the default mode network in mild cognitive impairment

Yaxuan Wang1, Qian Li1, Li Yao1

  • 1Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular lmaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Wuhou District, Chengdu 610041, Sichuan Province, P.R. China.

Cerebral Cortex (New York, N.Y. : 1991)
|March 24, 2024
PubMed

Insights

Alzheimer's disease (AD) and mild cognitive impairment (MCI) share decreased default mode network (DMN) functional connectivity, impacting memory. However, distinct DMN alterations in AD suggest broader cognitive deficits.

Area of Science:

  • Neuroscience
  • Cognitive Neurology
  • Medical Imaging

Background:

  • Alzheimer's disease (AD) and mild cognitive impairment (MCI) exhibit altered default mode network (DMN) resting-state functional connectivity (rsFC).
  • The extent of shared DMN rsFC abnormalities between MCI and AD remains unclear.

Conclusions:

  • Shared decreased within-DMN rsFC in MCI and AD may underlie episodic memory deficits and neuropsychiatric symptoms.
  • Distinct DMN rsFC alterations in AD suggest potential differences in language, vision, and executive function impairments.
  • Findings offer insights into the neuropathological mechanisms differentiating MCI and AD stages.
Keywords:
Alzheimer’s diseasedefault mode networkmeta-analysismild cognitive impairmentresting-state functional connectivity

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