Acceptability and anticipated effectiveness of a safe supply of opioids, among people who inject opioids in King County, WA
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Most people who inject opioids find a regulated supply acceptable and believe it would significantly lower overdose risk. This study highlights the need for pragmatic solutions to reduce exposure to unregulated drugs in Washington state.
Area Of Science
- Public Health
- Addiction Medicine
- Epidemiology
Background
- Opioid overdose deaths in the U.S. surpass one million in two decades.
- A regulated opioid supply could mitigate overdose deaths by reducing exposure to illicit drugs.
- This study explores the feasibility of regulated opioid models among individuals who inject opioids in Seattle.
Purpose Of The Study
- To assess the acceptability of regulated opioid supply models.
- To determine preferred delivery methods for regulated opioids.
- To evaluate the perceived impact of regulated supply on overdose risk.
Main Methods
- Utilized data from the 2022 Seattle-area National HIV Behavior Surveillance (NHBS) survey.
- Recruited participants using respondent-driven sampling between July and December 2022.
- Surveyed 453 participants who inject opioids regarding regulated supply acceptability, delivery preferences, and perceived risk reduction.
Main Results
- 81% of participants found a regulated opioid supply acceptable.
- The preferred models were take-home prescription (35%), no-prescription dispensary (28%), and on-site prescription (13%).
- 69% anticipated a "a lot less risky" experience, and 20% "a little less risky" compared to their current unregulated supply.
Conclusions
- A regulated opioid supply is acceptable to the majority of individuals who inject opioids.
- Participants anticipate significant reductions in overdose risk with access to regulated opioids.
- Pragmatic strategies are crucial to decrease reliance on unregulated drugs amid rising overdose deaths in Washington state.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...