The effect of propofol on effective brain networks
D van Blooijs1, S Blok2, G J M Huiskamp2
1UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, PO Box 85500, 3584 GA Utrecht, The Netherlands; Stichting Epilepsie Instellingen Nederland (SEIN), P.O.box 540, 2130 AM Hoofddorp, The Netherlands.
Summary
Propofol anesthesia reduces the number of effective brain connections detected by single pulse electrical stimulation (SPES) during electrocorticography (ECoG). However, the overall brain network topology remains largely preserved under propofol.
Area of Science:
- Neuroscience
- Anesthesiology
- Epilepsy Research
Background:
- Intracranial electrocorticography (ECoG) is crucial for epilepsy surgery planning.
- Understanding the effects of anesthesia on brain networks is vital for interpreting ECoG data.
Purpose of the Study:
- To investigate the impact of propofol anesthesia on effective brain networks derived from ECoG.
- To compare network measures and cortico-cortical evoked potentials (CCEPs) between awake and anesthetized states.
Main Methods:
- Nine epilepsy patients undergoing ECoG were studied.
- Single Pulse Electrical Stimulation (SPES) was administered during both awake (SPES-clinical) and propofol-anesthesia (SPES-propofol) states.
- Effective networks were constructed, and network measures (indegree, outdegree, betweenness centrality), N1-peak latency, and amplitude of CCEPs were compared.
Main Results:
- Fewer CCEPs were observed under propofol anesthesia.
- Significant correlations were found for indegree, outdegree, and betweenness centrality between the two states.
- N1-peak latency of CCEPs increased under propofol anesthesia.
Conclusions:
- Propofol anesthesia decreases the number of effective network connections but marginally affects network measures.
- The primary topology of effective brain networks is preserved under propofol anesthesia.
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