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Updated: Jun 30, 2025
A Simplified Technique for Producing an Ischemic Wound Model
Published on: May 2, 2012
Topical oxygen therapy and singlet oxygen in wound healing: A scoping review
Martina Sýkorová1, Christine Joy Moffatt2, Neil Stentiford3
1Skin Integrity Research Group, School of Health Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, UK.
Abstract:
The aim of this scoping review was to provide an overview of current research into topical oxygen therapies including the under-researched singlet oxygen for wound healing. A scoping review was undertaken using five databases. After duplicates and ineligible studies were excluded, 49 studies were included for a narrative review. Out of the included 49 studies, 45 (91.8%) were published in the past 10 years (2013-2023) with 32 (65.3%) published in the past 5 years (2018-2023). Eight of the studies were systematic reviews and/or meta-analysis and 18 were RCTs. The search identified zero human RCTs on singlet oxygen, but one human cohort study and five studies in animals. There is evidence that topical oxygen therapy may be useful for the treatment of chronic wounds, mainly diabetic foot ulcers. Singlet oxygen has shown potential, but would need further confirmation in controlled human trials, including more research to understand the bio-properties.
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