Nomogram for personalized prognostic assessment of children with favorable histology Wilms tumor: A retrospective analysis

Zihong Wang ¹, Jiayi Li ¹, Pei Liu ¹

⁰Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China, 100045.

Urologic Oncology +

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March 24, 2024

View abstract on PubMed

Summary

A new nomogram helps predict outcomes for favorable histology Wilms tumor (FHWT) patients. This tool uses clinical and pathological data to improve prognostic accuracy and guide treatment decisions for pediatric kidney cancer.

Area Of Science

Pediatric Oncology
Cancer Prognostics
Wilms Tumor Research

Background

Favorable histology Wilms tumor (FHWT) requires accurate prognostic tools.
Personalized risk assessment is crucial for optimizing treatment strategies.

Purpose Of The Study

To develop and validate a nomogram for predicting event-free survival (EFS) in FHWT patients.
To identify key clinical and pathological predictors of FHWT outcomes.

Main Methods

Retrospective analysis of 401 FHWT patients treated between 2007 and 2022.
Univariate and multivariate Cox regression analyses to identify significant prognostic factors.
Construction and validation of a predictive nomogram using identified variables.

Main Results

The nomogram incorporated age, stage, and histological risk as independent predictors of EFS.
The nomogram demonstrated good calibration and high predictability (AUCs 0.85-0.88 for 1-5 year EFS).
Older age (>2 years) and high-risk histology were associated with worse prognosis.

Conclusions

The developed nomogram is a valuable tool for assessing FHWT patient prognosis.
Accurate staging and histological risk assessment are vital for informed clinical decision-making.
The nomogram facilitates personalized treatment planning for pediatric kidney cancer.

Keywords:

Nomogram Predictors Prognosis Wilms tumor