Nomogram for personalized prognostic assessment of children with favorable histology Wilms tumor: A retrospective...

Area of Science:

• Pediatric Oncology
• Cancer Prognostics
• Wilms Tumor Research

Background:

• Favorable histology Wilms tumor (FHWT) requires accurate prognostic tools.
• Personalized risk assessment is crucial for optimizing treatment strategies.

Purpose of the Study:

• To develop and validate a nomogram for predicting event-free survival (EFS) in FHWT patients.
• To identify key clinical and pathological predictors of FHWT outcomes.

Main Methods:

• Retrospective analysis of 401 FHWT patients treated between 2007 and 2022.
• Univariate and multivariate Cox regression analyses to identify significant prognostic factors.
• Construction and validation of a predictive nomogram using identified variables.

Main Results:

• The nomogram incorporated age, stage, and histological risk as independent predictors of EFS.
• The nomogram demonstrated good calibration and high predictability (AUCs 0.85-0.88 for 1-5 year EFS).
• Older age (>2 years) and high-risk histology were associated with worse prognosis.

Conclusions:

• The developed nomogram is a valuable tool for assessing FHWT patient prognosis.
• Accurate staging and histological risk assessment are vital for informed clinical decision-making.
• The nomogram facilitates personalized treatment planning for pediatric kidney cancer.