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Updated: May 14, 2026

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

Semi-Bone Tunnel Technique Using Double-Row Suture Bridge Combined With Platelet-Rich Plasma Hydrogel for Rotator

Shengqiang Zeng¹, Jiacheng Sun², Bo Qin¹

¹Department of Orthopedics, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.

The American Journal of Sports Medicine

|March 25, 2024

Summary

The semi-bone tunnel (SBT) technique with platelet-rich plasma (PRP) hydrogel significantly improved rotator cuff tendon-bone healing in rabbits. This approach offers a promising alternative for rotator cuff repair, mimicking natural tissue structure and function.

Keywords:

all-suture anchor platelet-rich plasma rotator cuff tear suture bridge tendon-bone interface healing

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Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

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Last Updated: May 14, 2026

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Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

Published on: March 31, 2023

Area of Science:

Orthopedic Surgery
Regenerative Medicine
Biomaterials Science

Background:

Optimal healing of rotator cuff tears hinges on effective management of the footprint area and reconstruction of the tendon-bone interface (TBI).
Current repair techniques face challenges in achieving robust tendon-to-bone integration.

Purpose of the Study:

To evaluate the efficacy of the semi-bone tunnel (SBT) technique combined with platelet-rich plasma (PRP) hydrogel for rotator cuff repair.
To compare the outcomes of SBT with PRP hydrogel against traditional methods in a rabbit model.

Main Methods:

A controlled laboratory study involving 48 New Zealand White rabbits with surgically induced supraspinatus tendon tears.
Treatment groups included traditional onto-surface repair, SBT technique, and SBT technique with PRP hydrogel implantation.
Assessment at 8 weeks included macroscopic observation, MRI, μCT, histology, and biomechanical testing.

Main Results:

The SBT+PRP group showed uniform tendon signal, minimal inflammation on MRI, and a 4-layer TBI structure histologically, similar to natural tissue.
μCT confirmed no significant bone mineral density reduction with the SBT technique.
Biomechanical tests revealed superior properties in the SBT+PRP group, comparable to the normal group.

Conclusions:

The SBT technique demonstrates superior tendon-bone healing compared to traditional repair in a rabbit rotator cuff tear model.
Combining SBT with PRP hydrogel effectively restores tendon-bone interface structure and biomechanical properties, closely resembling natural tissue.