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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
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Multimorbidity in Atherosclerotic Cardiovascular Disease and Its Associations With Adverse Cardiovascular Events and
Dingwei Dai1, Joaquim Fernandes1, Xiaowu Sun1
1CVS Health, Woonsocket, Rhode Island, USA.
Journal of Health Economics and Outcomes Research
|March 25, 2024
Summary
Patients with atherosclerotic cardiovascular disease (ASCVD) often have numerous comorbidities, increasing adverse cardiovascular events and healthcare costs. Managing this multimorbidity is crucial for secondary prevention.
Area of Science:
- Cardiology
- Public Health
- Health Economics
Background:
- Atherosclerotic cardiovascular disease (ASCVD) is a leading global cause of death and disability.
- High prevalence of multimorbidity complicates ASCVD management and outcomes.
Purpose of the Study:
- To evaluate the burden of multimorbidity in ASCVD patients.
- To examine associations between multimorbidity, adverse cardiovascular events (ACEs), and healthcare costs.
Main Methods:
- Retrospective cohort study using Aetna claims data (2018-2021).
- Identified ASCVD patients with at least 12 months pre/post-index enrollment.
- Utilized association rule mining for comorbidity patterns and generalized linear models for outcome analysis.
Main Results:
- Nearly all ASCVD patients (98.5%) had ≥2 comorbidities; 80.2% had ≥5.
- Mean comorbidity count was 7.1, increasing with age, and higher in females and socially vulnerable individuals.
- Increased comorbidity number strongly correlated with higher ACEs and healthcare costs.
Conclusions:
- Multimorbidity is extremely common in ASCVD patients.
- Comorbidity patterns differ by demographics and social vulnerability.
- Addressing multimorbidity is essential for ASCVD secondary prevention and cost management.
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