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Related Experiment Videos

A three-year clinical trial with levonorgestrel silastic implants.

S Diaz, M Pavez, D N Robertson

    Contraception
    |June 1, 1979
    PubMed
    Summary

    Levonorgestrel implants provide effective long-term contraception, with no pregnancies reported in three years. While irregular bleeding was a side effect, overall acceptability was high, suggesting potential for wider use.

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    Area of Science:

    • Reproductive Medicine
    • Endocrinology
    • Contraception

    Background:

    • Long-term contraceptive methods are crucial for family planning.
    • Levonorgestrel implants offer a progestin-based hormonal option.

    Purpose of the Study:

    • To evaluate the efficacy and safety of Silastic implants containing levonorgestrel as a long-term contraceptive.
    • To assess continuation rates and identify adverse effects over a three-year period.

    Main Methods:

    • 101 women used levonorgestrel-releasing Silastic implants for up to three years.
    • Data collected on pregnancy occurrence, continuation rates, and side effects.
    • Biochemical parameters (blood, urine) and glucose tolerance tests were monitored.

    Main Results:

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    • Zero pregnancies occurred over 2,998 woman-months of use.
    • Continuation rates were 87% (12 mo), 79% (24 mo), and 66% (36 mo).
    • Irregular bleeding was the primary side effect; other effects included headache, acne, and abdominal pain. Most lab values remained normal, with a trend toward lower cortisol.

    Conclusions:

    • Levonorgestrel implants are highly effective for pregnancy prevention over three years.
    • The method demonstrates good acceptability with manageable side effects, warranting further investigation.
    • Introducing treatments for bleeding irregularities could improve continuation rates and justify larger trials.