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Updated: Jun 29, 2025
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Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy
Published on: August 22, 2018
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Engineering vascularized skin-mimetic phantom for non-invasive Raman spectroscopy
Piyush Raj1, Lintong Wu1, Saransh Arora1
1Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Sensors and Actuators. B, Chemical
|March 25, 2024
Summary
Researchers developed a novel skin phantom for Raman spectroscopy metabolite sensing. This standardized phantom mimics skin
Area of Science:
- Biomedical Optics
- Spectroscopy
- Biomaterials
Background:
- Raman spectroscopy offers non-invasive analyte sensing potential.
- Lack of standardized optical phantoms hinders progress in Raman spectroscopy.
- Existing phantoms have high Raman scattering, complicating metabolite signal detection.
Purpose of the Study:
- To develop a standardized, skin-mimetic optical phantom for Raman spectroscopy.
- To enable accurate metabolite sensing in a physiologically relevant model.
- To advance the development of minimally invasive optical techniques.
Main Methods:
- Developed a layered, skin-mimetic phantom.
- Incorporated millifluidic vasculature to mimic blood vessels and metabolite diffusion.
- Ensured mechanical properties mimic biological tissue.
Main Results:
- The phantom supports metabolite sensing via Raman spectroscopy.
- Millifluidic vasculature facilitates realistic metabolite diffusion.
- Mechanically mimetic properties are suitable for optical technique development.
Conclusions:
- The developed skin phantom provides a standardized platform for Raman spectroscopy.
- This phantom facilitates metabolite sensing and improves understanding of in vivo metabolite dynamics.
- Enables advancements in spectroscopic techniques for biomedical applications.
