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Microbial Biosensors01:17

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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
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Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
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An ultra-sensitive biosensor based on surface plasmon resonance and weak value amplification.

Lizhong Zhang1, Mingyi He2, Yang Xu1

  • 1Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.

Frontiers in Chemistry
|March 25, 2024
PubMed
Summary

A novel weak measurement surface plasmon resonance (WMSPR) biosensor enhances IgG detection sensitivity. This phase-based sensor achieves significantly higher refractive index sensitivity and a lower limit of detection for improved biosensing applications.

Keywords:
biomolecular interactionbiosensorrefractive index sensorsurface plasmon resonanceweak value amplification

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Area of Science:

  • Plasmonics
  • Biosensing
  • Optical Metrology

Background:

  • Surface Plasmon Resonance (SPR) is a widely used technique for label-free biosensing.
  • Enhancing the sensitivity and resolution of SPR sensors remains a critical challenge for detecting low-concentration analytes.
  • Phase-based detection methods offer potential advantages over traditional intensity-based SPR.

Purpose of the Study:

  • To propose and demonstrate an ultra-sensitive phase plasmonic sensor for IgG detection.
  • To leverage weak value amplification (WVA) to enhance the refractive index sensitivity of an SPR system.
  • To investigate the performance of the proposed WMSPR biosensor in terms of sensitivity, resolution, and limit of detection.

Main Methods:

  • Development of a WMSPR biosensor based on a gold-coated prism-coupled SPR structure.
  • Utilizing self-interference between p- and s-polarized light for phase detection.
  • Employing a phase compensator and WVA principles to modulate coupling strength and amplify phase shifts.

Main Results:

  • The WMSPR sensor achieved a high refractive index sensitivity of 4.737 × 10^4 nm/RIU, approximately three times higher than conventional phase-based SPR.
  • Demonstrated a high resolution of 6.333 × 10^-8 RIU.
  • Achieved a low limit of detection (LOD) of 5.3 ng/mL for IgG detection.

Conclusions:

  • The proposed WMSPR biosensor significantly enhances sensitivity and resolution for biomolecule detection.
  • The integration of WVA with phase-based SPR offers a promising strategy for developing next-generation ultra-sensitive biosensors.
  • This approach has broad implications for optimizing other SPR-based sensing platforms.